Evidence map›Paper›PMID 41375198›Full record

ArticleMolecules (Basel, Switzerland)2025

Ocular Toxicity and Mechanistic Investigation for Berberine and Its Metabolite Berberrubine on Zebrafish.

Ting Liu, Jia Tang, Xinyi Lu, Lu Jiang, Rui Zhang, Miaoqing Zhang, Jingpu Zhang, Danqing Song, Dousheng Zhang, Mingzhe Xu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Ting LiuInstitute for Food Control, National Institutes for Food and Drug Control, Beijing 102629, China.ORCID 0000-0002-3715-0411
Jia TangInstitute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.
Xinyi LuInstitute for Drug Control, National Institutes for Food and Drug Control, Beijing 102629, China.
Lu JiangDivision of Science and Technology, Department of Science, Technology and International Cooperation, National Medical Products Administration, Beijing 100037, China.
Rui ZhangInstitute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.
Miaoqing ZhangInstitute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.
Jingpu ZhangInstitute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.
Danqing SongInstitute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.ORCID 0000-0002-2557-5009
Dousheng ZhangInstitute for Drug Control, National Institutes for Food and Drug Control, Beijing 102629, China.ORCID 0009-0005-2533-786X
Mingzhe XuInstitute for Drug Control, National Institutes for Food and Drug Control, Beijing 102629, China.

Funding

NMPA Key Laboratory for Quality Research and Evaluation of Chemical Drugs Project 2024HYZX13State Key Laboratory of Drug Regulatory Science Project 2025SKLDRS0311
6 · The paper itself

Abstract

Berberine (BBR) has seen growing application in ophthalmology, yet the ocular toxicity of BBR and its metabolites remains poorly understood. This study aimed to evaluate the ocular toxicity of BBR and its major metabolite M1 and unravel their underlying mechanisms. Ocular toxicity was evaluated in human corneal epithelial cells and wild-type AB zebrafish. Mechanistic studies utilized fluorescence imaging, biochemical quantitative assays, and qPCR analyses in AB zebrafish and transgenic mitochondrial fluorescent zebrafish (strain

Indexed as

BerberineEyeAnimalsAnimals, Genetically ModifiedApoptosisAutophagyHumansMitochondriaOxidative StressZebrafishBerberineBBRBBR metabolitesmitochondrial dysfunctionocular toxicitySirtuin 3

Identifiers

PMID41375198
PMCPMC12693135

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.