Evidence map›Paper›PMID 41375205›Full record

ArticleMolecules (Basel, Switzerland)2025

Promising Anticancer Activity of Novel Hydroxyethyloxy and Bromo derivatives of Curcumin and Its Complexes with BF

Eduard Potapskyi, Dawid Lazewski, Julian Myszkiewicz, Gabriela Korzańska, Joanna Kuzminska, Łukasz Popenda, Artur Korzański, Agnieszka Zgoła-Grześkowiak, Agnieszka Gielara-Korzańska, Karolina Chmaj-Wierzchowska and 6 more

Abstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Enhancement of antitumor activity through structural optimization of 2-(Benzylamino)-thieno[2,3-d]pyrimidin-4(3H)-ones.Medicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents · 2026
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Eduard PotapskyiDepartment of Chemical Technology of Drugs, Poznan University of Medical Sciences, Rokietnicka Street 3, 60-806 Poznan, Poland.ORCID 0000-0002-5248-1091
Dawid LazewskiDepartment of Chemical Technology of Drugs, Poznan University of Medical Sciences, Rokietnicka Street 3, 60-806 Poznan, Poland.ORCID 0000-0002-9832-5094
Julian MyszkiewiczDepartment of Chemical Technology of Drugs, Poznan University of Medical Sciences, Rokietnicka Street 3, 60-806 Poznan, Poland.
Gabriela KorzańskaDepartment of Chemical Technology of Drugs, Poznan University of Medical Sciences, Rokietnicka Street 3, 60-806 Poznan, Poland.ORCID 0009-0000-6037-5056
Joanna KuzminskaDepartment of Pharmaceutical Chemistry, Poznan University of Medical Sciences, Rokietnicka Street 3, 60-806 Poznan, Poland.ORCID 0000-0002-8514-5238
Łukasz PopendaNanoBioMedical Centre, Adam Mickiewicz University, Wszechnicy Piastowskiej Street 3, 61-614 Poznan, Poland.ORCID 0000-0003-1117-3081
Artur KorzańskiDepartment of Chemistry, Adam Mickiewicz University, Uniwersytetu Poznanskiego Street 8, 61-614 Poznan, Poland.ORCID 0000-0001-6207-6914
Agnieszka Zgoła-GrześkowiakInstitute of Chemistry and Technical Electrochemistry, Poznan University of Technology, Berdychowo Street 4, 60-965 Poznan, Poland.ORCID 0000-0002-9722-4769
Agnieszka Gielara-KorzańskaDepartment of Chemical Technology of Drugs, Poznan University of Medical Sciences, Rokietnicka Street 3, 60-806 Poznan, Poland.ORCID 0009-0004-4362-2915
Karolina Chmaj-WierzchowskaDepartment of Maternal and Child Health, Poznan University of Medical Sciences, 60-701 Poznan, Poland.ORCID 0000-0003-2299-8353
Nataliya FiniukDepartment of Regulation of Cell Proliferation and Apoptosis, Institute of Cell Biology of the National Academy of Sciences of Ukraine, Drahomanov Street 14/16, 79005 Lviv, Ukraine.ORCID 0000-0002-4112-8815
Yuliia KozakDepartment of Regulation of Cell Proliferation and Apoptosis, Institute of Cell Biology of the National Academy of Sciences of Ukraine, Drahomanov Street 14/16, 79005 Lviv, Ukraine.ORCID 0000-0002-6793-0662
Iryna IvasechkoDepartment of Regulation of Cell Proliferation and Apoptosis, Institute of Cell Biology of the National Academy of Sciences of Ukraine, Drahomanov Street 14/16, 79005 Lviv, Ukraine.ORCID 0000-0003-2789-0763
Rostyslav StoikaDepartment of Regulation of Cell Proliferation and Apoptosis, Institute of Cell Biology of the National Academy of Sciences of Ukraine, Drahomanov Street 14/16, 79005 Lviv, Ukraine.ORCID 0000-0001-5719-2187
Roman LesykMolecular Design Center, State Non-Commercial Enterprise, Danylo Halytsky Lviv National Medical University, Pekarska Street 69, 79010 Lviv, Ukraine.ORCID 0000-0002-3322-0080
Marcin WierzchowskiDepartment of Chemical Technology of Drugs, Poznan University of Medical Sciences, Rokietnicka Street 3, 60-806 Poznan, Poland.ORCID 0000-0003-2619-0466

Funding

National Research Foundation of Ukraine 2023.03/0104National Science Centre 2019/35/B/NZ7/01165
6 · The paper itself

Abstract

Curcumin has long been used for health purposes and is currently attracting significant research interest. In this study, we present a series of curcumin derivatives featuring structural modifications, including methoxy groups, short alcohol chains, and bromine atoms. The cytotoxic activity of the compounds obtained was tested against BA/F3 wt, BA/F3 del52, BA/F3 ins5, K562, Jurkat, HCT-116, and MDA-MB-231 cell lines and non-cancerous Balb/3T3 fibroblast lines. The most promising compounds

Indexed as

Antineoplastic AgentsCurcuminAnimalsApoptosisCell Line, TumorCell ProliferationCell SurvivalDrug Screening Assays, AntitumorHCT116 CellsHumansMiceMolecular StructureReactive Oxygen SpeciesStructure-Activity RelationshipAntineoplastic AgentsCurcuminReactive Oxygen Speciesanticancer activitybrominecurcumincurcumin derivatives

Identifiers

PMID41375205
PMCPMC12693189

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.