Evidence map›Paper›PMID 41375212›Full record

ArticleMolecules (Basel, Switzerland)2025

Garlic-Derived Phytochemical Candidates Predicted to Disrupt SARS-CoV-2 RBD-ACE2 Binding and Inhibit Viral Entry.

Martha Susana García-Delgado, Aldo Fernando Herrera-Rodulfo, Karen Y Reyes-Melo, Ashly Mohan, Fernando Góngora-Rivera, Jesús Andrés Pedroza-Flores, Alma D Paz-González, Gildardo Rivera, María Del Rayo Camacho-Corona, Mauricio Carrillo-Tripp

Abstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Martha Susana García-DelgadoBiomolecular Diversity Laboratory, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional Unidad Monterrey, Vía del Conocimiento 201, PIIT, Apodaca 66600, Nuevo León, Mexico.ORCID 0009-0007-2705-2168
Aldo Fernando Herrera-RodulfoBiomolecular Diversity Laboratory, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional Unidad Monterrey, Vía del Conocimiento 201, PIIT, Apodaca 66600, Nuevo León, Mexico.ORCID 0000-0003-1279-7697
Karen Y Reyes-MeloFacultad de Ciencias Químicas, Universidad Autónoma de Nuevo León, Avenida Universidad s/n, Ciudad Universitaria, San Nicolás de los Garza 66455, Nuevo León, Mexico.ORCID 0009-0009-2044-581X
Ashly MohanFacultad de Ciencias Químicas, Universidad Autónoma de Nuevo León, Avenida Universidad s/n, Ciudad Universitaria, San Nicolás de los Garza 66455, Nuevo León, Mexico.
Fernando Góngora-RiveraFacultad de Medicina, Universidad Autónoma de Nuevo León, Av. Dr. José Eleuterio González 235, Mitras Centro, Monterrey 64460, Nuevo León, Mexico.
Jesús Andrés Pedroza-FloresFacultad de Agronomía, Universidad Autónoma de Nuevo León, Francisco Villa S/N, Col. Exhacienda El Canadá, General Escobedo 66050, Nuevo León, Mexico.
Alma D Paz-GonzálezLaboratorio de Biotecnología Farmacéutica, Centro de Biotecnología Genómica, Instituto Politécnico Nacional, Reynosa 88710, Tamaulipas, Mexico.
Gildardo RiveraLaboratorio de Biotecnología Farmacéutica, Centro de Biotecnología Genómica, Instituto Politécnico Nacional, Reynosa 88710, Tamaulipas, Mexico.ORCID 0000-0001-9842-4167
María Del Rayo Camacho-CoronaFacultad de Ciencias Químicas, Universidad Autónoma de Nuevo León, Avenida Universidad s/n, Ciudad Universitaria, San Nicolás de los Garza 66455, Nuevo León, Mexico.ORCID 0000-0001-8179-7231
Mauricio Carrillo-TrippBiomolecular Diversity Laboratory, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional Unidad Monterrey, Vía del Conocimiento 201, PIIT, Apodaca 66600, Nuevo León, Mexico.ORCID 0000-0003-0060-6486

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The emergence of SARS-CoV-2 and its rapid global spread underscores the urgent need for novel therapeutic strategies. This study investigates the antiviral potential of

Indexed as

Angiotensin-Converting Enzyme 2Antiviral AgentsGarlicPhytochemicalsPlant ExtractsSARS-CoV-2Spike Glycoprotein, CoronavirusVirus InternalizationCOVID-19COVID-19 Drug TreatmentHumansMolecular Docking SimulationProtein BindingACE2 protein, humanAngiotensin-Converting Enzyme 2Antiviral AgentsPhytochemicalsPlant ExtractsSpike Glycoprotein, Coronavirusspike protein, SARS-CoV-2Allium sativumbioactive metabolite identificationcomputational drug discoverydrug-likenesspharmacokinetic profiling

Identifiers

PMID41375212
PMCPMC12692970

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.