Quercetin Enhances the Antibacterial Activity of Polymyxin E Against MCR-1-Positive Bacteria by Inhibiting the Biological Functions of the Cell Membrane.

Yongjie Zhang, Liyang Guo, Shun Wang, Jie Zhang, Xinlei Ren, Rui Li, Jichang Li, Chunli Chen

Abstract read

In one paragraph

Article in Animals : an open access journal from MDPI, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

Bioactive Profile, Antioxidant, andAntioxidants (Basel, Switzerland) · 2026
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Yongjie ZhangCollege of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, China.ORCID 0009-0008-2261-4894

Liyang GuoCollege of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, China.ORCID 0000-0003-2681-7505

Shun WangCollege of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, China.ORCID 0009-0000-3323-4266

Jie ZhangCollege of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, China.ORCID 0009-0006-5398-2855

Xinlei RenCollege of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, China.ORCID 0009-0002-9370-7939

Rui LiCollege of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, China.ORCID 0000-0001-9159-2969

Jichang LiCollege of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, China.ORCID 0000-0002-1779-1190

Chunli ChenCollege of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, China.ORCID 0000-0002-1151-5582

Funding

International Postdoctoral Exchange Fellowship Program from the Office of China Postdoctoral Council No. 2020106National Natural Science Foundation of Heilongjiang Province (No. YQ2022C017Postdoctoral Foundation of Heilongjiang Province LBH-Z19006

6 · The paper itself

Abstract

In animal husbandry and livestock farming, with the spread of the plasmid-mediated MCR-1 gene, polymyxin E, as the last line of defense against drug-resistant Gram-negative bacteria, is facing severe challenges. This study investigated the in vitro and in vivo synergistic effects and mechanisms of QUE combined with polymyxin E against MCR-1-positive chicken

Indexed as

antibiotic resistancecombined medicationEscherichia coliMCR-1quercetin

Identifiers

PMID41375548

DOI10.3390/ani15233491

PMCPMC12690987

What Socratic holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.