ArticleHGG advances2026
Leveraging large-scale biobanks for therapeutic target discovery.
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Article in HGG advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1citing papers in PubMed
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1 citing paper in PubMed.
- A genomic-led strategy to anticipate drug safety effects.PLoS genetics · 2026Article
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Authors and funding
44 authors.
Brian R FerolitoMillion Veteran Program (MVP) Coordinating Center, Veterans Affairs Healthcare System, 2 Avenue de Lafayette, Boston, MA 02111, USA. Electronic address: brian.ferolito@va.gov.
Hesam DashtiMillion Veteran Program (MVP) Coordinating Center, Veterans Affairs Healthcare System, 2 Avenue de Lafayette, Boston, MA 02111, USA; Division of Aging, Brigham and Women's Hospital and Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA; Broad Institute of MIT and Harvard, 415 Main Street, Cambridge, MA 02142, USA.
Claudia GiambartolomeiHealth Data Science Centre, Human Technopole, V.le Rita Levi-Montalcini, 1, 20157 Milan, Italy; Centre for Human Technologies (CHT), Insituto Italiano di Tecnologia, Via Enrico Melen 83, Building B, 7th Floor, 16152 Genova, Italy.
Gina M PelosoMillion Veteran Program (MVP) Coordinating Center, Veterans Affairs Healthcare System, 2 Avenue de Lafayette, Boston, MA 02111, USA; Department of Biostatistics, Boston University School of Public Health, Crosstown Center, 801 Massachusetts Avenue, Boston, MA 02115, USA.
Daniel J GoldenMillion Veteran Program (MVP) Coordinating Center, Veterans Affairs Healthcare System, 2 Avenue de Lafayette, Boston, MA 02111, USA; Division of Aging, Brigham and Women's Hospital and Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA.
Kai Gravel-PucilloMillion Veteran Program (MVP) Coordinating Center, Veterans Affairs Healthcare System, 2 Avenue de Lafayette, Boston, MA 02111, USA; Division of Aging, Brigham and Women's Hospital and Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA.
Danielle RasoolyMillion Veteran Program (MVP) Coordinating Center, Veterans Affairs Healthcare System, 2 Avenue de Lafayette, Boston, MA 02111, USA; Division of Aging, Brigham and Women's Hospital and Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA.
Andrea R V R HorimotoMillion Veteran Program (MVP) Coordinating Center, Veterans Affairs Healthcare System, 2 Avenue de Lafayette, Boston, MA 02111, USA; Division of Aging, Brigham and Women's Hospital and Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA.
Rachael MattyMillion Veteran Program (MVP) Coordinating Center, Veterans Affairs Healthcare System, 2 Avenue de Lafayette, Boston, MA 02111, USA.
Liam GazianoMillion Veteran Program (MVP) Coordinating Center, Veterans Affairs Healthcare System, 2 Avenue de Lafayette, Boston, MA 02111, USA; BHF Cardiovascular Epidemiology Unit, University of Cambridge, Cambridge CB2 0BB, UK.
Yi LiuMRC Integrative Epidemiology Unit, Bristol Medical School, Bristol BS8 1QU, UK.
Ines A SmitEuropean Molecular Biology Laboratory, European Bioinformatics Institute, Hinxton CB10 1SD, UK.
Barbara ZdrazilEuropean Molecular Biology Laboratory, European Bioinformatics Institute, Hinxton CB10 1SD, UK.
Yakov TsepilovOpen Targets, Hinxton CB10 1SD, UK.
Lauren CostaMillion Veteran Program (MVP) Coordinating Center, Veterans Affairs Healthcare System, 2 Avenue de Lafayette, Boston, MA 02111, USA.
Nicole KosikMillion Veteran Program (MVP) Coordinating Center, Veterans Affairs Healthcare System, 2 Avenue de Lafayette, Boston, MA 02111, USA.
Jennifer E HuffmanMillion Veteran Program (MVP) Coordinating Center, Veterans Affairs Healthcare System, 2 Avenue de Lafayette, Boston, MA 02111, USA; VA Palo Alto Healthcare System, Palo Alto, CA 94304, USA; Department of Medicine, Harvard Medical School, Boston, MA 02115, USA.
Gian Gaetano TartagliaCentre for Human Technologies (CHT), Insituto Italiano di Tecnologia, Via Enrico Melen 83, Building B, 7th Floor, 16152 Genova, Italy; ICREA - Institució Catalana de Recerca i Estudis Avançats, Passeig Llúis Companys 23, 08010 Barcelona, Spain.
Giorgio BiniCentre for Human Technologies (CHT), Insituto Italiano di Tecnologia, Via Enrico Melen 83, Building B, 7th Floor, 16152 Genova, Italy; Università degli Studi di Genova, Via Balbi 5, 16126 Genova, Italy.
Gabriele ProiettiCentre for Human Technologies (CHT), Insituto Italiano di Tecnologia, Via Enrico Melen 83, Building B, 7th Floor, 16152 Genova, Italy.
Harris IoannidisEuropean Molecular Biology Laboratory, European Bioinformatics Institute, Hinxton CB10 1SD, UK.
Mohd A KarimGenomic Discovery, Variant Bio, Seattle, WA 98109, USA.
Fiona HunterEuropean Molecular Biology Laboratory, European Bioinformatics Institute, Hinxton CB10 1SD, UK.
Gibran HemaniMRC Integrative Epidemiology Unit, Bristol Medical School, Bristol BS8 1QU, UK.
Adam S ButterworthBHF Cardiovascular Epidemiology Unit, University of Cambridge, Cambridge CB2 0BB, UK; NIHR Blood and Transplant Research Unit in Donor Health and Behaviour, University of Cambridge, Cambridge CB2 0BB, UK; Victor Phillip Dahdaleh Heart and Lung Research Institute, University of Cambridge, Cambridge CB2 0BB, UK; British Heart Foundation Centre of Research Excellence, School of Clinical Medicine, Addenbrooke's Hospital, University of Cambridge, Cambridge CB2 0BB, UK; Health Data Research UK Cambridge, Wellcome Genome Campus, and University of Cambridge, Cambridge CB2 0BB, UK.
Emanuele Di AngelantonioHealth Data Science Centre, Human Technopole, V.le Rita Levi-Montalcini, 1, 20157 Milan, Italy; BHF Cardiovascular Epidemiology Unit, University of Cambridge, Cambridge CB2 0BB, UK; NIHR Blood and Transplant Research Unit in Donor Health and Behaviour, University of Cambridge, Cambridge CB2 0BB, UK; Victor Phillip Dahdaleh Heart and Lung Research Institute, University of Cambridge, Cambridge CB2 0BB, UK; British Heart Foundation Centre of Research Excellence, School of Clinical Medicine, Addenbrooke's Hospital, University of Cambridge, Cambridge CB2 0BB, UK; Health Data Research UK Cambridge, Wellcome Genome Campus, and University of Cambridge, Cambridge CB2 0BB, UK.
Claudia LangenbergPrecision Healthcare University Research Institute, Queen Mary University of London, London, UK; Computational Medicine, Berlin Institute of Health at Charité - Universitätsmedizin, Berlin, Germany; MRC Epidemiology Unit, University of Cambridge, Cambridge CB2 0SR, UK.
Maya GhoussainiRegeneron Genetics Center, Regeneron Pharmaceuticals, Tarrytown, NY 10591, USA.
Andrew R LeachEuropean Molecular Biology Laboratory, European Bioinformatics Institute, Hinxton CB10 1SD, UK; Open Targets, Hinxton CB10 1SD, UK.
Katherine P LiaoMedicine, Rheumatology, VA Boston Healthcare System, 150 S. Huntington, Boston, MA 02130, USA; Division of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital and Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA; Department of Biomedical Informatics, Harvard Medical School, Boston, MA 02115, USA.
Scott DamrauerCorporal Michael Crescenz VA Medical Center, Philadelphia, PA 19104, USA; Department of Genetics, University of Pennsylvania, Perelman School of Medicine, Philadelphia, PA 19104, USA; Department of Surgery, University of Pennsylvania, Perelman School of Medicine, Philadelphia, PA 19104, USA; Cardiovascular Institute, University of Pennsylvania, Perelman School of Medicine, Philadelphia, PA 19104, USA.
Luis E SelvaMillion Veteran Program (MVP) Coordinating Center, Veterans Affairs Healthcare System, 2 Avenue de Lafayette, Boston, MA 02111, USA; Radiology, Boston University, Chobanian and Avedisian School of Medicine, 72 East Concord Street, Boston, MA 02118, USA.
Stacey WhitbourneMillion Veteran Program (MVP) Coordinating Center, Veterans Affairs Healthcare System, 2 Avenue de Lafayette, Boston, MA 02111, USA; Division of Aging, Brigham and Women's Hospital and Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA; Department of Medicine, Harvard Medical School, Boston, MA 02115, USA.
Philip S TsaoPalo Alto Veterans Institute for Research (PAVIR), VA Palo Alto Healthcare System, Palo Alto, CA 94304, USA; Department of Medicine, Stanford University, Palo Alto, CA 94304, USA.
Jennifer MoserOffice of Research and Development, Department of Veterans Affairs, Washington, DC 20420, USA.
Tom GauntMRC Integrative Epidemiology Unit, Bristol Medical School, Bristol BS8 1QU, UK.
Tianxi CaiDepartment of Biomedical Informatics, Harvard Medical School, Boston, MA 02115, USA.
John C WhittakerMRC Biostatistics Unit, University of Cambridge, Cambridge CB2 0SR, UK.
Million Veteran Program
Juan P CasasBiomarker Development/Translational Medicine, Novartis Institutes for Biomedical Research, 250 Massachusetts Avenue, Cambridge, MA 02139, USA.
Sumitra MuralidharOffice of Research and Development, Department of Veterans Affairs, Washington, DC 20420, USA.
J Michael GazianoMillion Veteran Program (MVP) Coordinating Center, Veterans Affairs Healthcare System, 2 Avenue de Lafayette, Boston, MA 02111, USA; Division of Aging, Brigham and Women's Hospital and Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA; Department of Medicine, Harvard Medical School, Boston, MA 02115, USA.
Kelly ChoMillion Veteran Program (MVP) Coordinating Center, Veterans Affairs Healthcare System, 2 Avenue de Lafayette, Boston, MA 02111, USA; Division of Aging, Brigham and Women's Hospital and Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA; Department of Medicine, Harvard Medical School, Boston, MA 02115, USA.
Alexandre C PereiraMillion Veteran Program (MVP) Coordinating Center, Veterans Affairs Healthcare System, 2 Avenue de Lafayette, Boston, MA 02111, USA; Division of Aging, Brigham and Women's Hospital and Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA; Department of Medicine, Harvard Medical School, Boston, MA 02115, USA.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Large biobanks, including the Million Veteran Program (MVP), the UK Biobank, and FinnGen, provide genetic association results for more than 1 million individuals for hundreds of phenotypes. To select targets for pharmaceutical development, as well as to improve the understanding of existing targets, we harmonized these studies and performed two-sample Mendelian randomization (MR) on 2,003 phenotypes using genetic variants associated with gene expression (derived from GTEx and eQTLGen) and plasma protein levels (derived from ARIC, Fenland, and deCODE) as proxies of target modulation. We found 69,669 gene-trait pairs with evidence (p ≤ 1.6 × 10
Indexed as
Biological Specimen BanksDrug DiscoveryMolecular Targeted TherapyGenome-Wide Association StudyHumansMendelian Randomization AnalysisPhenotypeQuantitative Trait LocigenomicsMendelian randomizationtarget identification
Identifiers
What Socratic holds
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LicenceCC BY
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.