Evidence map›Paper›PMID 41376216›Full record

ArticleJournal of traditional Chinese medicine = Chung i tsa chih ying wen pan2025

Electroacupuncture alleviates type 2 diabetes mellitus by promoting plasma-derived exosomal circular RNA of enhancer of zeste homolog 1 expression.

Shou Yin, Jiang Juntao, H U Jianlin, J I Wei, Chen Chunyan, H U Li, M A Yuhang, Zhang Bimeng

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Acupuncture-driven exosomes: an emerging therapy.Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan · 2026
    Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Shou YinDepartment of Acupuncture-Moxibustion, Shanghai General Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200000, China.
Jiang JuntaoDepartment of Urology, Shanghai General Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200000, China.
H U JianlinDepartment of Reproduction, Shanghai General Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200000, China.
J I WeiDepartment of Traditional Chinese Orthopedics, Xiangshan TCM Hospital, Shanghai, China.
Chen ChunyanShanghai Research Institute of Qigong, Taiji Health Center, Shanghai University of Traditional Chinese Medicine, Shanghai 200000, China.
H U LiAcumox and Tuina Research Section, College of Acumox and Tuina, Shanghai University of Traditional Chinese Medicine, Shanghai 200000, China.
M A YuhangDepartment of Endorcinolgy and Metabolism, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200000, China.
Zhang BimengDepartment of Acupuncture-Moxibustion, Shanghai General Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200000, China.

Funding

Science and Technology Committee of Songjiang District, Shanghai 2024SJKJGG001the Science and Technology Commission of Shanghai Municipality Project: a Randomized Controlled Study of Traditional Chinese Acupuncture Combined with Rehabilitation Training for the Treatment of Intensive Care Unit-Acquired Weakness 20511101204the Shanghai Municipal Health Bureau project: Mechanistic Study on the Therapeutic Effect of Electroacupuncture in Diabetic OsteoporosisExosomal circular RNA of Enhancer of Zeste Homolog 1-Regulated miR-128/ Transient Receptor Potential Vanilloid 1 Axis-Mediated Ferroptosis in Osteoclasts 2020LP010the Shanghai University of Traditional Chinese Medicine Project: Traditional Chinese Medicine Data Collection and Governance for Early Screening and Stratified Diagnosis and Treatment of Pancreatic Cancer 2021LK100the Southern Outpatient Party Branch and Shanghai Municipal Commission of Health and Family Planning Project: Research on the Construction of Talent Evaluation System by the Southern Outpatient Party Branch ZY(2021-2023)-0208Wellcome Trust 202220
6 · The paper itself

Abstract

objectiveTo investigate the effect of electroacupuncture (EA) on regulatory functions of one specific exosomal circRNA of Enhancer of Zeste Homolog (CircEZH) and its potential mechanisms of action in type 2 diabetes (T2DM).

methodsMice were fed a high-fat diet (HFD) and intraperitoneally injected with streptozotocin to create the T2DM model and then were used for two experiments involving the following groups: experiment 1 (control group, T2DM group, T2DM+EA group, 10 mice per group) and experiment 2 [control group, T2DM group, T2DM+ CircEZH1-siRNA (20 nmol/20 g) group, 10 mice per group]. Exosomal size, distribution, and morphology were evaluated

resultsEA treatment significantly reduced the serum insulin level and cell apoptosis in pancreatic tissue in a T2DM model. EA treatment markedly upregulated CircEZH1 expression in the exosomes of T2DM mice. Further study showed that CircEZH1 overexpression resulted in increased Min6 cell viability and decreased Min6 cell apoptosis when compared with the levels in an overexpression control group. In Min6 cells with CircEZH1 knockout, the opposite trends were identified. CircEZH1-knockout Min6 cells also showed reduced insulin expression.

conclusionsEA can affect CircEZH1 expression specifically in the exosomes in β cells in the pancreatic islets to improve T2DM. Exosomal CircEZH1 is a potential therapeutic candidate to treat T2DM.

Indexed as

Diabetes Mellitus, Type 2ElectroacupunctureExosomesRNA, CircularAnimalsHumansInsulinMaleMiceMice, Inbred C57BLInsulinRNA, Circulardiabetes mellitus, type 2diet, high-fatelectroacupunctureexosomal CircEZH1

Identifiers

PMID41376216
PMCPMC12703693

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.