ArticleJournal of traditional Chinese medicine = Chung i tsa chih ying wen pan2025
Mechanisms of Suanzaoren () and its processed products in treating insomnia: an integrated study based on network pharmacology and metabolomics.
Article in Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Role of gamma-aminobutyric acid-ergic neurons in the thalamic reticular nucleus in regulating sleep-wake cycles in mice treated with acupuncture for insomnia.Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan · 2026Article
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Authors and funding
9 authors.
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Abstract
objectiveTo elucidate the potential mechanisms and identify bioactive components of Suanzaoren (
methodsThe principal components of ZSS and its processed products were analyzed using Ultra-Performance liquid chromatography quadrupole time-of-flight mass spectrometry (UPLC-Q-TOF-MS). The effects of ZSS on insomnia were assessed in para-chlorophenylalanine (PCPA)-induced rats. Additionally, to investigate the mechanisms of action in insomnia, serum and hippocampal non-targeted metabolomics were performed alongside network pharmacology and molecular docking.
resultsUPLC-Q-TOF-MS was used to analyze the main components of ZSS and its processed products. In the insomnia rat model induced by PCPA, both ZSS and its processed products demonstrated therapeutic effects, with the processed products showing particularly significant effects, significantly increasing the levels of the Gamma-Aminobutyric Acid and melatonin. Non-targeted metabolomics identified 23 and 10 potential differential metabolites in serum and hippocampus, respectively, involving pathways such as lipid metabolism and amino acid metabolism. Network pharmacology identified three core targets, mainly associated with pathways such as Transient Receptor Potential channel regulation, Advanced Glycation End-products-Receptor for Advanced Glycation End-products signaling pathway, and neuroactive ligand-receptor interaction. Molecular docking confirmed that the main active components of ZSS can stably bind to these core targets, thereby exerting an effect in improving insomnia.
conclusionsCombining
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Registered trials
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