ArticleCureus2025
Comparative Long-Term Outcomes of Vertebroplasty Versus Kyphoplasty for Osteoporotic Vertebral Compression Fractures: A Propensity-Matched Analysis.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction Vertebroplasty and kyphoplasty are widely performed for osteoporotic vertebral compression fractures (VCFs). The objective of this study was to compare long-term clinical outcomes between patients undergoing vertebroplasty and kyphoplasty for osteoporotic VCFs. Methods We used the TriNetX US Collaborative Research Platform to identify adults aged ≥50 years with osteoporotic VCFs treated with vertebroplasty or kyphoplasty between 2000 and 2025. Patients with malignancy were excluded. Cohorts were propensity-matched 1:1 (7,528 per cohort) on demographic, comorbidity, and bone health variables. Outcomes were assessed using International Classification of Diseases-10 (ICD-10) and Current Procedural Terminology (CPT) codes: subsequent fractures (one year), short-term neurologic/functional complications (one month), opioid prescriptions (one year), repeat augmentation (two years), and all-cause mortality (five years). Results Patients treated with kyphoplasty had a higher one-year risk of subsequent vertebral fractures compared with vertebroplasty (4,196 (55.7%) vs 3,905 (51.9%); HR 0.89; 95% CI 0.85-0.93; p < 0.001). Patients undergoing vertebroplasty experienced more short-term neurologic complications, including spinal cord compression (HR 1.19; 95% CI 1.08-1.31; p < 0.001), radiculopathy (HR 1.19; 95% CI 1.06-1.33; p = 0.004), and difficulty walking (HR 2.15; 95% CI 1.65-2.79; p < 0.001). The two-year risk of repeat vertebral augmentation did not differ meaningfully between procedures (1,111 (14.8%) vs 1,069 (14.2%); HR 1.00; 95% CI 0.90-1.10; p = 0.90). Five-year all-cause mortality was similar between vertebroplasty and kyphoplasty (HR 1.04; 95% CI 0.99-1.10; p = 0.13). Conclusion Vertebroplasty and kyphoplasty demonstrated comparable long-term survival and repeat procedure rates, but differed in specific risk profiles. Kyphoplasty carried a modestly higher risk of subsequent fractures, whereas vertebroplasty was associated with more short-term complications and earlier, more frequent opioid use. These findings should inform procedure selection in patients with osteoporotic VCFs.
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