ArticleAnnals of medicine and surgery (2012)2025
Examining the French paradox: a systematic review of red wine consumption and cardiovascular risk.
Article in Annals of medicine and surgery (2012), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Microglial Activation Under Hypoxic Conditions in Early Alzheimer's Disease: Can Natural SIRT1 Activators Be Therapeutic Allies in the Inflammation-Energy Axis?Phytotherapy research : PTR · 2026Review
Corrections and comments
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Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: The French paradox, characterized by a lower prevalence of coronary heart disease (CHD) despite a diet rich in saturated fats, challenges conventional beliefs linking saturated fat intake to CHD risk. Despite high saturated fat consumption, the French exhibit lower CHD rates, sparking interest in the potential cardiovascular benefits of red wine (RW), a staple of the Mediterranean diet rich in polyphenols like resveratrol. Objectives: The objective of this systematic review is to examine the potential advantages of RW and its components in enhancing cardiovascular health among patients with CHD. Methods: Following Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, a thorough search of PubMed, Cochrane, ScienceDirect, and Google Scholar was conducted to identify relevant studies published from inception to July 2024. Eligible studies investigating the association between RW consumption and cardiovascular risk factors/outcomes within the French paradox context were included. Data extraction and eligibility criteria ensured methodological rigor. Results: Of the 812 studies initially screened, 36 met the inclusion criteria in accordance with the PRISMA guidelines. Among these, 28 reported positive effects of RW on cardiovascular parameters, including improvements in lipid profiles, reductions in inflammatory markers, enhanced endothelial function, and modulation of gut microbiota. Two studies identified adverse effects, while six found no significant associations. Collectively, these findings suggest that moderate RW consumption - attributable primarily to its polyphenolic compounds such as resveratrol - may confer cardioprotective benefits, particularly in patients with CHD. Conclusion: This review supports the French paradox by highlighting that moderate RW consumption may improve cardiovascular health through lipid modulation, endothelial function, and anti-inflammatory effects - mainly due to its polyphenols rather than alcohol. However, individual responses and lifestyle factors may influence outcomes, warranting further research.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.