ArticleAnnals of medicine and surgery (2012)2025
MTHFR C677T polymorphism and T2DM risk in Iraqi Kurds: a cross-sectional study.
Article in Annals of medicine and surgery (2012), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background/objectives: Type 2 diabetes mellitus (T2DM) represents a major global health problem, and the methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism has been repeatedly linked to T2DM susceptibility. However, no prior study has investigated this association in the Iraqi Kurdish population. This study aimed to examine the relationship between the MTHFR C677T polymorphism and T2DM in a sample of Iraqi Kurdish patients, and to evaluate its effects on metabolic parameters, lipid profiles, and the incidence of diabetic complications. Materials and methods - Participants and study designs: Diabetic Center in Azadi Teaching Hospital - from various districts of the Duhok Governorate - at the Duhok Blood Bank. - The study protocol was approved by the General Directorate of Health Ethics Committee, Duhok, Kurdistan Region, Iraq (protocol code: 29052024-4-5; approval date: 29 March 2024). Questionnaire: Of the Duhok Diabetic Center. Genetic testing of MTHFR C677T polymorphism: Blood samples were obtained at the Duhok Diabetic Center in Azadi Teaching Hospital and subsequently transported to the Duhok Central Laboratory for genetic analysis. Discussion: From the Duhok Governorate. Results: Compared with controls, T2DM patients had higher blood pressure (BP), waist circumference (WC), body mass index (BMI), and glycated hemoglobin (HbA1c) ( Conclusions: The MTHFR C677T polymorphism is strongly associated with T2DM in Iraqi Kurdish patients, with the T allele linked to adverse metabolic profiles and a higher risk of complications. These findings highlight the potential clinical value of incorporating genetic screening into early risk assessment and personalized management strategies in high-risk populations.
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