ArticleAnnals of medicine and surgery (2012)2025
Efficacy and safety of celiac plexus radiotherapy in Pancreatic cancer-related pain management: a systematic review and meta-analysis.
Article in Annals of medicine and surgery (2012), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
11 authors.
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Abstract
Background: Advanced cancer pain, especially in pancreatic cancer, often requires interventional management. This meta-analysis evaluates the effectiveness and safety of celiac plexus radiotherapy in reducing pain, providing comprehensive insights for oncologic pain management. Methods: A systematic search was conducted on PubMed, Embase, and Cochrane databases through October 2024. The primary outcome was the BPI-SF (Brief Pain Inventory-Short Form) pain score reduction at 3 weeks. Data were analyzed using random-effects models, with heterogeneity assessed by Results: This meta-analysis included 4 randomized controlled trials with 141 participants, median age 64.25 years. Most patients (91.75%) had pancreatic cancer. BPI-SF pain scores showed significant reductions at 3 weeks (RR -4.59, 95% CI: -7.77 to -1.42, Conclusion: Celiac plexus radiotherapy appears effective in reducing cancer-related pain at 3- and 6-week post-procedure with minimal impact on morphine use. It demonstrates a favorable safety profile, making it a promising option for managing advanced cancer pain.
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