Evidence map›Paper›PMID 41377406›Full record

ArticleAnnals of medicine and surgery (2012)2025

Risk of thyroid dysfunction after COVID-19 vaccination: meta-analysis of 11 million individuals.

Noheir Ashraf Ibrahem Fathy Hassan, Eman A Toraih, Menna A Shebl, Amaan Usmani, Amr Ossama Gaber Arafa, Mohamed Mohamed Elnouty, Ayesha Laraib-Ijaz, Uday Atwal, Deepak Gir, Helen A O Samuel and 5 more

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Article in Annals of medicine and surgery (2012), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

15 authors.

Noheir Ashraf Ibrahem Fathy HassanFaculty of Medicine, Aswan University, Aswan, Egypt.
Eman A ToraihDepartment of Cardiovascular Perfusion, College of Health Professions, Upstate Medical University, New York, NY, USA.
Menna A SheblFaculty of Medicine, Modern University for Technology and Information, Cairo, Egypt.
Amaan UsmaniSkaneateles Central High School, Skaneateles, NY, USA.
Amr Ossama Gaber ArafaFaculty of Medicine, Alexandria University, Alexandria, Egypt.
Mohamed Mohamed ElnoutyFaculty of Medicine, Cairo University, Cairo, Egypt.
Ayesha Laraib-IjazDepartment of Internal Medicine, University Of Missouri, Kansas City, USA.
Uday AtwalFayetteville-Manlius High School, Manlius, NY, USA.
Deepak GirDepartment of Internal Medicine, St. Joseph's Medical Center, Stockton, USA.
Helen A O SamuelSt. George University School of medicine, Grenada, West Indies.
Mazen HassaninFaculty of Medicine, Cairo University, Cairo, Egypt.
Nayiira SalimFaculty of Medicine, Alexandria University, Alexandria, Egypt.
Jaffer ShahDepartment of Ophthalmology, Weill Cornell Medicine, New York, NY, USA.
Yusef HazimehDepartment of Internal Medicine, Division of Endocrinology, American University of Beirut, Beirut, Lebanon.ORCID https://orcid.org/0000-0002-5090-5997
Hani AiashDepartment of Cardiovascular Perfusion, College of Health Professions, Upstate Medical University, New York, NY, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: To mitigate the SARS-CoV-2 pandemic, the worldwide rollout of COVID-19 vaccinations has been essential. Potential links between the COVID-19 vaccine and several thyroid disorders, like subacute thyroiditis, Graves' disease, and thyroiditis, were shown by early case reports and short observational studies. The goal of this systematic review and meta-analysis is to assess the relationship between several COVID-19 vaccinations and thyroid conditions. Methods: We conducted a comprehensive search of major databases through February 2025, adhering to Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) criteria. Thyroid dysfunction after COVID-19 vaccination was the main outcome measure used in our analysis of 21 studies. Specific thyroid dysfunctions (Graves' disease, hyperthyroidism, hypothyroidism, thyroiditis, and thyroid eye disease) were among the secondary outcomes. For every meta-analysis, we used random-effects models based on the Der Simonian and Laird approach, considering the anticipated clinical and methodological heterogeneity among trials. Results: Single-arm meta-analysis revealed thyroid dysfunction prevalence of 8.54% [95% confidence interval (CI) 3.45-19.61%] among vaccinated individuals compared to 31.78% (95% CI: 14.18-56.79%) in unvaccinated populations ( Conclusion: This thorough meta-analysis offers comforting proof of the COVID-19 vaccines' safety for the thyroid, with some protective benefits against Graves' disease and mostly neutral relationships with other thyroid conditions.

Indexed as

COVID-19Graves’ diseasethyroidvaccination

Identifiers

PMID41377406
PMCPMC12688942

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.