ArticleAnnals of medicine and surgery (2012)2025
P4HB regulates tumor-associated macrophage polarization and chemotaxis by enhancing IL-6 cytokine secretion in glioblastoma.
Article in Annals of medicine and surgery (2012), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Prolyl 4-hydroxylase subunit beta (P4HB) has been linked to glioma progression and treatment resistance; however, its role in the tumor microenvironment regulation remains unclear. Materials and Methods: A total of 90 human glioma samples and 30 normal traumatic brain injury (TBI) tissues from patients undergoing surgical resection were collected from the First Affiliated Hospital of Zhengzhou University for immunohistochemical (IHC) staining. The signaling pathway mechanism regulating prognosis and tumor proliferation was explored through bioinformatics analysis and functional assays via Results: The IHC analysis of 90 glioma and 30 TBI tissues revealed that P4HB expression correlated with tumor malignancy, especially the WHO grade 4 and grade 2 ( Conclusion: These findings establish P4HB as a regulator of glioma progression via IL-6/STAT3-mediated microglial polarization, highlighting its potential as a therapeutic target for GBM.
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