Evidence map›Paper›PMID 41377507›Full record

ArticlebioRxiv : the preprint server for biology2025

Assessment of the Role of Telocyte Zbtb16 in Lymphatic Drainage using Efhd1-CreERT2 x Zbtb16

Yue Peng, Edward M Schwarz

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Yue PengCenter for Musculoskeletal Research; University of Rochester Medical Center.ORCID 0000-0001-5524-4772
Edward M SchwarzCenter for Musculoskeletal Research; University of Rochester Medical Center.ORCID 0000-0002-4854-9698

Funding

Rochester Resource-Based Center for Bone, Muscle and Orthopaedic Research (ROCSTARR) (Overall Application)P30AR069655 · NIAMS · UNIVERSITY OF ROCHESTER · PI Edward M. Schwarz · 2016 to 2026
$7.8M
Elucidating the Mechanisms of Arthritic Flare and Developing TreatmentsR01AR056702 · NIAMS · UNIVERSITY OF ROCHESTER · PI SCHWARZ, EDWARD M. · 2009 to 2025
$4.9M
NIAMS NIH HHS P30 AR069655NIAMS NIH HHS R01 AR056702
6 · The paper itself

Abstract

Lymphatic function is critical for maintaining fluid homeostasis and immune surveillance in synovial tissues, and its dysfunction is implicated in the progression of rheumatoid arthritis and osteoarthritis. Zbtb16, a transcription factor involved in cellular differentiation that is downregulated in mice with inflammatory arthritis and lymphatic defects, has been linked to skeletal development and immune regulation, but its direct role in lymphatic function remains unexplored. To investigate this, we generated Zbtb16

Identifiers

PMID41377507
PMCPMC12687777

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.