ArticleNutrition research and practice2025
N-3 highly unsaturated fatty acids combined with pro-biotics or post-biotics synergistically alleviate dyslipidemia in rats exposed to chronic mild stress.
Article in Nutrition research and practice, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
BACKGROUND/
objectivesThis research is objective to examine the synergistic hypocholesterolemic effects of n-3 highly unsaturated fatty acids (HUFA) combined with pro- or post-biotics on dyslipidemia caused by chronic mild stress (CMS) through modulating biosynthesis and clearance of cholesterol. MATERIALS/
methodsRats were assigned into 7 random groups, each containing 8 rats: n-3 HUFA deficient diet without CMS, CMS with n-3 HUFA deficient diet, pro-biotics, post-biotics, n-3 HUFA, n-3 HUFA with pro-biotics, and n-3 HUFA with post-biotics. The induction of CMS occurred over 5 weeks during the 12-week dietary supplementation period.
resultsThe n-3 HUFA, pro-biotics, and post-biotics ameliorated dyslipidemia caused by CMS and downregulated cholesterol biosynthesis through decreasing sterol regulatory element-binding protein-2 (biotics,
conclusionTherefore, n-3 HUFA with pro-biotics or post-biotics exert synergistic hypocholesterolemic effects on dyslipidemia induced by CMS through regulating biosynthesis and cholesterol clearance.
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