SynthesisFrontiers in medicine2025
Meta-analysis of Niaoduqing Granules for uremic pruritus in Chinese hemodialysis patients: efficacy and safety evidence from RCTs.
Synthesis in Frontiers in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- The Mechanism and Application of Traditional Chinese Medicine Nano-Formulations in the Treatment of Renal Fibrosis.International journal of nanomedicine · 2026Review
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Uremic pruritus, a common complication in hemodialysis populations, adversely affects quality of life owing to multifactorial etiology. Emerging evidence from traditional Chinese medicine highlights Niaoduqing Granules as a candidate intervention for symptom mitigation. To assess its therapeutic potential, a retrospective meta-analysis was performed to evaluate efficacy and safety profiles in hemodialysis cohorts. These findings aim to inform evidence-based decisions regarding its clinical applicability. Methods: A systematic literature search was conducted across four international biomedical databases (e.g., PubMed, Embase, Web of Science, ClinicalTrials.gov) and three Chinese scholarly platforms (CNKI, Wanfang, CQVIP), with the search window extending through March 2025. We systematically reviewed all available randomized controlled trials (RCTs) investigating the effects of Niaoduqing Granules on uremic pruritus in hemodialysis populations. Results: The final analysis incorporated 14 qualifying studies involving 1,232 participants. Hemodialysis patients receiving Niaoduqing Granules demonstrated a significant reduction in pruritus scores compared to the control group (Visual Analogue Scale: WMD = -2.151; 95% CIs = -2.372 to -1.930; Conclusion: Niaoduqing Granules demonstrated efficacy in reducing pruritus severity among hemodialysis patients without increasing drug-related adverse events, while also showing concomitant reductions in inflammatory biomarkers. However, limitations in sample size necessitate further large-scale studies to validate these preliminary findings.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.