Evidence map›Paper›PMID 41377938›Full record

ArticleFrontiers in endocrinology2025

Morning cortisol as an indicator of arterial stiffness in patients with type 2 diabetes: prospective cohort study and Mendelian randomization study.

Zhuomeng Hu, Lin Sun, Ying Peng, Juan Shi, Yihua Guo, Qianhua Fang, Cong Liu, Xing Wei, Jie Hong, Weiqiong Gu and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in endocrinology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Zhuomeng Hu *Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Lin Sun *Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Ying Peng *Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Juan Shi *Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Yihua GuoDepartment of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Qianhua FangDepartment of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Cong LiuDepartment of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Xing WeiDepartment of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Jie HongDepartment of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Weiqiong GuDepartment of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Weiwei ZhouDepartment of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Weiqing WangDepartment of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Yifei ZhangDepartment of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Elevated cortisol levels have been linked to arterial stiffness, but the evidence for this association remains controversial. We aimed to elucidate this relationship and to explore potential mediation pathways. Methods: To investigate the relationship between morning cortisol and arterial stiffness, two approaches were employed. First, we used linear mixed-effects (LME) models and mediation analysis in a prospective cohort study (n=1,235; average follow-up of 3.5 years) in type 2 diabetes (T2D), featuring repeated brachial-ankle pulse wave velocity (baPWV) measurements (2-8 per participant; 4,143 total) to assess arterial stiffness. Second, a two-step Mendelian randomization (MR) study was conducted using summary data of genome-wide association studies (GWAS) of CORtisol NETwork (CORNET) and UK Biobank (UKB). Arterial stiffness was measured by baPWV in the cohort study, with coronary atherosclerosis from UKB serving as the validation outcome. Results: The prospective study included participants with a mean age of 54.3 ± 11.3 years (65.3% male) and a mean baseline baPWV of 16.06 ± 3.23 m/s. It revealed that each 1-unit increase in log Conclusions: This research provides both observational and genetic evidence indicating a potential causal relationship between morning cortisol and arterial stiffness, with SBP as a key mediator.

Indexed as

Diabetes Mellitus, Type 2HydrocortisoneVascular StiffnessAdultAgedAnkle Brachial IndexBiomarkersCircadian RhythmCohort StudiesFemaleGenome-Wide Association StudyHumansMaleMendelian Randomization AnalysisMiddle AgedProspective StudiesBiomarkersHydrocortisonearterial stiffnesscohort studycoronary atherosclerosiscortisolMendelian randomizationtype 2 diabetes

Identifiers

PMID41377938
PMCPMC12685639

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.