Evidence map›Paper›PMID 41377943›Full record

ArticleFrontiers in endocrinology2025

Comparative efficacy of r-hFSH Alfa + r-LH versus r-hFSH delta + hMG in poor ovarian responders.

Giorgio Maria Baldini, Domenico Baldini, Dario Lot, Antonio Malvasi, Antonio Simone Laganà, Mario Palumbo, Gianluca Raffaello Damiani, Giuseppe Trojano

Erratum issuedAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in endocrinology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Giorgio Maria BaldiniObstetrics and Gynecology Unit, Department of Biomedical Sciences and Human Oncology, University of Bari "Aldo Moro", Bari, Italy.
Domenico BaldiniIVF Center, Momo Fertilife, Bisceglie, Italy.
Dario LotIVF Center, Momo Fertilife, Bisceglie, Italy.
Antonio MalvasiObstetrics and Gynecology Unit, Department of Biomedical Sciences and Human Oncology, University of Bari "Aldo Moro", Bari, Italy.
Antonio Simone LaganàUnit of Obstetrics and Gynecology, "Paolo Giaccone" Hospital, Department of Health Promotion, Mother and Childcare, Internal Medicine and Medical Specialties (PROMISE), University of Palermo, Palermo, Italy.
Mario PalumboDepartment of Public Health, School of Medicine, University of Naples "Federico II", Naples, Italy.
Gianluca Raffaello DamianiObstetrics and Gynecology Unit, Department of Biomedical Sciences and Human Oncology, University of Bari "Aldo Moro", Bari, Italy.
Giuseppe TrojanoDepartment of Maternal and Child Health, Madonna Delle Grazie Hospital, Matera, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Poor ovarian response (POR) remains a major limitation in assisted reproductive medicine. Direct comparisons between r-hFSH alfa + r-LH and r-hFSH delta + hMG in this population are scarce. Methods: This retrospective study included 437 POR patients treated between 2018 and 2022. Controlled ovarian stimulation involved either r-hFSH alfa + r-LH (Group A) or r-hFSH delta + hMG (Group B). After exclusions, 148 patients per group who reached embryo transfer were analyzed. Primary outcomes were total oocytes, metaphase II (MII) oocytes and embryos. Secondary outcomes included β-hCG positivity, clinical pregnancy and pharmacoeconomic evaluation. Results: Group A showed significantly higher numbers of oocytes (p=0.01), MII oocytes (p=0.02) and embryos (p=0.03). No significant differences in biochemical or clinical pregnancy were observed (OR 1.12; 95% CI: 0.79-1.59). The r-hFSH alfa + r-LH protocol required lower total gonadotropin doses and resulted in an average saving of €690 per additional MII oocyte. Discussion: The r-hFSH alfa + r-LH regimen improved ovarian response and cost-efficiency without affecting pregnancy outcomes. Prospective randomized trials are needed to confirm these results.

Indexed as

Follicle Stimulating Hormone, HumanLuteinizing HormoneMenotropinsOvulation InductionAdultEmbryo TransferFemaleFertilization in VitroHumansPregnancyPregnancy RateRecombinant ProteinsRetrospective StudiesTreatment OutcomeFollicle Stimulating Hormone, Humanfollitropin deltaLuteinizing HormoneMenotropinsRecombinant Proteinscontrolled ovarian stimulationpoor responderrFSHRLHstimulation protocol

Identifiers

PMID41377943
PMCPMC12685669

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.