ArticleJournal of the American Heart Association2025
Identification and Validation of Differentially Expressed mRNAs From Peripheral Leukocytes for Acute Stanford Type A Aortic Dissection.
Article in Journal of the American Heart Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Authors and funding
12 authors.
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Abstract
backgroundAcute Stanford type A aortic dissection (ATAAD) is lethal and has a high mortality rate, but few useful biomarkers are available for its diagnosis. This study aimed to identify and validate differentially expressed mRNAs in ATAAD from peripheral leukocytes.
methodsRNA sequencing was performed using peripheral blood leukocyte samples from 8 patients with ATAAD and 20 controls to screen differentially expressed mRNAs. A 2-stage case-control study consisting of 178 patients with ATAAD and 178 healthy controls was conducted to validate the 20 upregulated and 20 downregulated differentially expressed mRNAs. Then, a stage 3 case-control study consisting of 64 patients with ATAAD, 64 patients with acute myocardial infarction, and 64 controls was used for discriminative evaluation. Receiver operating characteristic curves were used to assess the diagnostic value of the differentially expressed mRNAs.
resultsA total of 35 mRNAs were successfully detected in stage 1, and 32 mRNAs presented differential expression (
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