ArticleJournal of the American Heart Association2025
Changes in Expression Profiles of Caspase-8 and Mixed Lineage Kinase Domain-Like Protein/Receptor-Interacting Protein Kinase 3 Mediated by Inflammation in Cerebral Arteriovenous Malformations Associated With Clinical Condition on Admission.
Article in Journal of the American Heart Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundCerebral arteriovenous malformations (cAVMs) are complex vascular anomalies carrying a high risk of hemorrhage due to abnormal arteriovenous connections. Recent studies have highlighted the roles of inflammation and
methodsWe analyzed tissue samples from 23 patients with cAVM in comparison with normal brain tissues. Proteome profiling, immunohistochemistry, and quantitative polymerase chain reaction assays were used to assess the expression of inflammatory molecules and programmed cell death markers.
resultsProtein and gene expression of necroptosis-related molecules (RIPK3, MLKL), caspase-8, and IL-6 (interleukin-6) and IL-8 were significantly elevated in cAVM nidi compared with normal brain tissue. High MLKL protein expression was associated with severe clinical presentations and hemorrhage, whereas caspase-8 protein expression was elevated in less-severe cases and unruptured cAVM.
conclusionOur analysis of human samples offers the first evidence of necroptosis-related molecules acting against caspase-8 in association with the inflammatory cytokines IL-6 and IL-8 in the pathogenesis of cAVM. The balance between MLKL and caspase-8 expression may be linked to the clinical condition and hemorrhagic presentation of patients with cAVM on admission.
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