ArticleJournal of the American Heart Association2025
Urine Tubular Biomarkers Are Associated With Natriuresis in Patients With Acute Heart Failure.
Article in Journal of the American Heart Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Urinary Biomarkers for the Risk Assessment and Management of Heart Failure: Pearls and Pitfalls.Current heart failure reports · 2026Review
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
backgroundLoop diuretics require functioning kidney tubules to increase the excretion of sodium into urine thereby relieving congestion in patients with acute heart failure (AHF). Whether biomarkers of kidney tubular health are associated with the natriuretic response of loop diuretics in AHF is unknown.
methodsSpot urine sodium and 14 urine biomarkers of tubular health were measured after intravenous loop diuretic administration on the day of enrollment in 418 patients with AHF from AKINESIS (Acute Kidney Injury Neutrophil Gelatinase-Associated Lipocalin [NGAL] Evaluation of Symptomatic Heart Failure Study). The association of each biomarker with urine sodium concentration was assessed with multivariable linear regression.
resultsThe mean age was 71±12 years, 64% were men, average estimated glomerular filtration rate was 56±24 mL/min per 1.73 m
conclusionsUrine biomarkers of tubular health are associated with lower natriuretic response to loop diuretics in patients with AHF. Kidney tubule health may be an underappreciated contributor to diuretic responsiveness in AHF.
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