Evidence map›Paper›PMID 41378506›Full record

ArticleJournal of the American Heart Association2025

Adjudicated Cardiovascular Events in Patients With COVID-19: Association With Vaccination Status and Changes over Time.

Behnood Bikdeli, Darsiya Krishnathasan, Antoine Bejjani, Candrika D Khairani, Nada Hamade, Umberto Campia, Julia Davies, Nicole Porio, Ali Assi, Andre Armero and 32 more

Abstract readMulticenter Study
In one paragraph

Article in Journal of the American Heart Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

42 authors.

Behnood BikdeliDivision of Cardiovascular Medicine, Brigham and Women's Hospital Harvard Medical School Boston MA USA.ORCID 0000-0003-1428-879X
Darsiya KrishnathasanDivision of Cardiovascular Medicine, Brigham and Women's Hospital Harvard Medical School Boston MA USA.ORCID 0000-0002-5405-2733
Antoine BejjaniDivision of Cardiovascular Medicine, Brigham and Women's Hospital Harvard Medical School Boston MA USA.ORCID 0000-0002-8975-7514
Candrika D KhairaniDivision of Cardiovascular Medicine, Brigham and Women's Hospital Harvard Medical School Boston MA USA.ORCID 0000-0003-3769-3501
Nada HamadeDivision of Cardiovascular Medicine, Brigham and Women's Hospital Harvard Medical School Boston MA USA.
Umberto CampiaDivision of Cardiovascular Medicine, Brigham and Women's Hospital Harvard Medical School Boston MA USA.ORCID 0000-0002-7894-3565
Julia DaviesDivision of Cardiovascular Medicine, Brigham and Women's Hospital Harvard Medical School Boston MA USA.ORCID 0000-0001-8165-2673
Nicole PorioDivision of Cardiovascular Medicine, Brigham and Women's Hospital Harvard Medical School Boston MA USA.ORCID 0009-0007-2786-9821
Ali AssiDivision of Cardiovascular Medicine, Brigham and Women's Hospital Harvard Medical School Boston MA USA.
Andre ArmeroDivision of Cardiovascular Medicine, Brigham and Women's Hospital Harvard Medical School Boston MA USA.ORCID 0009-0000-9486-3672
Anthony TristaniDivision of Cardiovascular Medicine, Brigham and Women's Hospital Harvard Medical School Boston MA USA.ORCID 0009-0002-4595-3975
Marcos D Ortiz-RiosDepartment of Medicine, Brigham and Women's Hospital Harvard Medical School Boston MA USA.
Victor NauffalDivision of Cardiovascular Medicine, Brigham and Women's Hospital Harvard Medical School Boston MA USA.ORCID 0000-0001-7199-299X
Zaid I AlmarzooqDivision of Cardiovascular Medicine, Brigham and Women's Hospital Harvard Medical School Boston MA USA.ORCID 0000-0001-5413-6219
Eric Q WeiDivision of Cardiovascular Medicine, Brigham and Women's Hospital Harvard Medical School Boston MA USA.ORCID 0000-0001-5948-0174
Bridget McGonagleDivision of Cardiovascular Medicine, Brigham and Women's Hospital Harvard Medical School Boston MA USA.
Mariana PfefermanDivision of Cardiovascular Medicine, Brigham and Women's Hospital Harvard Medical School Boston MA USA.
Sina RashediDivision of Cardiovascular Medicine, Brigham and Women's Hospital Harvard Medical School Boston MA USA.ORCID 0000-0003-0146-5611
Alyssa SatoDivision of Cardiovascular Medicine, Brigham and Women's Hospital Harvard Medical School Boston MA USA.ORCID 0009-0004-3979-9929
Giovanni ScimecaThrombosis Research Group, Brigham and Women's Hospital Harvard Medical School Boston MA USA.
Valeria Zuluaga-SánchezThrombosis Research Group, Brigham and Women's Hospital Harvard Medical School Boston MA USA.ORCID 0009-0005-6808-5439
Mehrdad ZarghamiDepartment of Medicine, Brigham and Women's Hospital Harvard Medical School Boston MA USA.ORCID 0000-0003-0549-951X
Aditya AchantaDivision of Cardiovascular Medicine, Brigham and Women's Hospital Harvard Medical School Boston MA USA.
Sirus JesudasenDivision of Pulmonary and Critical Care Medicine Massachusetts General Hospital Boston MA USA.ORCID 0000-0002-2962-1228
Bruce C TiuThrombosis Research Group, Brigham and Women's Hospital Harvard Medical School Boston MA USA.ORCID 0000-0002-2815-5579
Geno J MerliDepartment of Cardiology Thomas Jefferson University Hospital Philadelphia PA USA.ORCID 0000-0002-8663-6872
Orly LeivaDepartment of Medicine, Brigham and Women's Hospital Harvard Medical School Boston MA USA.ORCID 0000-0002-3006-6380
John FanikosDepartment of Pharmacy, Brigham and Women's Hospital Harvard Medical School Boston MA USA.ORCID 0000-0002-4218-2637
Aditya M SharmaDepartment of Medicine, Cardiovascular Medicine University of Virginia Health Charlottesville VA USA.
Samantha M RizzoThrombosis Research Group, Brigham and Women's Hospital Harvard Medical School Boston MA USA.ORCID 0000-0003-2759-8287
Ruth B MorrisonDivision of Cardiovascular Medicine, Brigham and Women's Hospital Harvard Medical School Boston MA USA.
Alec VishnevskyDepartment of Cardiology Thomas Jefferson University Hospital Philadelphia PA USA.
Shiavax J RaoDepartment of Medicine, Cardiovascular Medicine University of Virginia Health Charlottesville VA USA.ORCID 0000-0002-7724-2089
Sivan NavehCPC Clinical Research Aurora CO USA.
Abdelghani El RafeiCPC Clinical Research Aurora CO USA.ORCID 0009-0008-9128-1341
James WelkerAnne Arundel Research Institute Annapolis MD USA.
Marc P BonacaCPC Clinical Research Aurora CO USA.ORCID 0000-0002-9860-3584
Brett J CarrollSmith Center for Cardiovascular Outcomes Research, Division of Cardiology, Beth Israel Deaconess Medical Center Harvard Medical School Boston MA USA.ORCID 0000-0002-6704-5663
Samuel Z GoldhaberDivision of Cardiovascular Medicine, Brigham and Women's Hospital Harvard Medical School Boston MA USA.ORCID 0000-0002-6450-0448
Zhou LanThrombosis Research Group, Brigham and Women's Hospital Harvard Medical School Boston MA USA.
Gregory PiazzaDivision of Cardiovascular Medicine, Brigham and Women's Hospital Harvard Medical School Boston MA USA.ORCID 0000-0003-1407-5276
CORONA‐VTE Network Investigators

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPatients with COVID-19 are at risk of thrombotic and cardiovascular complications. Existing risk estimates derive from early COVID-19 experiences. More recent event rates, temporal trends, and the association between vaccination status and cardiovascular outcomes remain unclear.

methodsThe CORONA-VTE Network (COVID-19 Registry to Assess Frequency, Risk Factors, Management, and Outcomes of Arterial and Venous Thromboembolic Complications) multicenter registry included patients with COVID-19 from March 2020 to February 2024. A composite of venous and arterial thrombotic events and a composite of adjudicated cardiovascular events were assessed at 90 days after COVID-19 diagnosis. Time-to-first-event analyses were stratified by inpatients and outpatients and adjusted for competing risks. Outcomes were adjudicated by independent physicians.

resultsOf 11 165 patients, 4451 were inpatients (mean age, 65 years; 47% women) and 462 of 4451 were admitted to the intensive care unit. Among inpatients, the 90-day cumulative incidences of thrombotic and cardiovascular events were 8.9% (95% CI, 8.0%-9.8%) and 15.6% (95% CI, 14.5%-16.7%), respectively. Corresponding estimates for patients in the intensive care unit were 20.0% (95% CI, 16.6%-24.0%) and 30.7% (95% CI, 26.8%-35.3%), while event rates were low among outpatients. There was an initial decline in cardiovascular events (adjusted hazard ratio [HR], 0.84;

conclusionsThrombotic and cardiovascular events are common in hospitalized patients with COVID-19, especially those in the intensive care unit, without a persistent decline over time. COVID-19 vaccination was associated with a reduced risk of cardiovascular events.

Indexed as

Cardiovascular DiseasesCOVID-19COVID-19 VaccinesThrombosisVaccinationAgedFemaleHospitalizationHumansIncidenceMaleMiddle AgedRegistriesRisk AssessmentRisk FactorsSARS-CoV-2COVID-19 VaccinescardiovascularCOVID‐19thrombosisvaccine

Identifiers

PMID41378506
PMCPMC12826919

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.