ArticleJournal of the American Heart Association2025
Loss of Lipin1 Contributes to Multiple Pathological Processes in the Development of Heart Failure.
Article in Journal of the American Heart Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
6 authors.
Funding
Abstract
backgroundLipin1 has dual functions acting as phosphatidic acid phosphatase required for lipid synthesis and as a transcriptional coactivator. Our previous research demonstrated that lipin1 is critical for maintaining sarcolemmal integrity in skeletal muscle. Given the importance of sarcolemmal stability for cardiac muscle viability and function, we investigated the role of lipin1 in the heart using a novel cardiac-specific lipin1 deficient (
methodsWe characterized male
results
conclusionsThese findings reveal a critical role for lipin1 in maintaining cardiac sarcolemmal integrity and emphasize its importance in supporting normal cardiac morphology and function, particularly under stress conditions.
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