ReviewBioscience reports2025
Bone morphogenetic protein (BMP)-9, a systemic homeostasis factor with diverse functions in the liver and beyond.
Review in Bioscience reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Pulpitis Transiently Affect Hepatic Bone Morphogenetic Protein 9 Expression by Lipopolysaccharide.International dental journal · 2026Article
- Canonical and emerging regulatory mechanisms of tissue remodeling: shared principles across organs and therapeutic opportunities.Frontiers in immunology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bone Morphogenetic Protein-9 (BMP-9), a circulating cytokine belonging to the TGF-β superfamily, is increasingly recognized as a critical regulator of tissue homeostasis with diverse roles in both health and disease. This review recapitulates current knowledge regarding BMP-9, shifting focus beyond its traditional association with bone formation to highlight its significant influence on physiology and pathology in the liver but also in other tissues and organs. We discuss how BMP-9 exerts intricate control over various cell types, affecting key processes such as angiogenesis, macrophage polarization, and regeneration. Intriguingly, while in the liver, BMP-9 contributes to the maintenance of sinusoidal endothelial cell quiescence and Kupffer cell identity, dysregulation of its signaling can as well promote fibrosis. The complexity of BMP-9 function is further compounded by its cross-talks with other signaling molecules like TGF-β, as well as non-Smad pathways. In this review, we summarize current knowledge about the functions of BMP-9 in humans and discuss its therapeutic potential.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.