Evidence map›Paper›PMID 41378776›Full record

ArticleeLife2025

The oocyte zinc transporter

Atsuko Kageyama, Narumi Ogonuki, Takuya Wakai, Takafumi Namiki, Yui Kawata, Manabu Ozawa, Yasuhiro Yamada, Toshiyuki Fukada, Atsuo Ogura, Rafael Fissore and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in eLife, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Atsuko KageyamaLaboratory of Animal Reproduction, School of Veterinary Medicine, Azabu University, Sagamihara, Japan.ORCID https://orcid.org/0009-0006-7486-5711
Narumi OgonukiBioresource Engineering Division, Bioresource Research Center, RIKEN, Tsukuba, Japan.
Takuya WakaiDepartment of Animal Science, Graduate School of Environmental and Life Science, Okayama University, Okayama, Japan.ORCID https://orcid.org/0000-0003-4705-8974
Takafumi NamikiLaboratory of Animal Reproduction, School of Veterinary Medicine, Azabu University, Sagamihara, Japan.
Yui KawataLaboratory of Animal Reproduction, School of Veterinary Medicine, Azabu University, Sagamihara, Japan.
Manabu OzawaLaboratory of Reproductive Systems Biology, Center for Experimental Medicine and Systems Biology, The Institute of Medical Science, The University of Tokyo, Minato-ku, Japan.
Yasuhiro YamadaDepartment of Molecular Pathology, Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Japan.
Toshiyuki FukadaLaboratory of Molecular and Cellular Physiology, Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Tokushima, Japan.
Atsuo OguraBioresource Engineering Division, Bioresource Research Center, RIKEN, Tsukuba, Japan.ORCID https://orcid.org/0000-0003-0447-1988
Rafael FissoreDepartment of Veterinary and Animal Sciences, University of Massachusetts Amherst, Amherst, United States.
Naomi KashiwazakiLaboratory of Animal Reproduction, School of Veterinary Medicine, Azabu University, Sagamihara, Japan.
Junya ItoLaboratory of Animal Reproduction, School of Veterinary Medicine, Azabu University, Sagamihara, Japan.ORCID https://orcid.org/0000-0001-9398-7358

Funding

Japan Science Society 2019-4044Japan Society for the Promotion of Science 15H04584Japan Society for the Promotion of Science 20H05373Japan Society for the Promotion of Science 21H02384Japan Society for the Promotion of Science 22H04268Japan Society for the Promotion of Science 22H04922Japan Society for the Promotion of Science 24H02601Japan Society for the Promotion of Science 24K23214Mishima Kaiun Memorial Foundation A-135
6 · The paper itself

Abstract

In all vertebrates studied to date, a rise(s) in intracellular calcium is indispensable for successful fertilization and further embryonic development. Recent studies demonstrated that zinc is ejected to the extracellular milieu, the 'zinc spark', and follows the first few calcium rises of fertilization. However, the role of the zinc sparks in fertilization and development, as well as the supporting influx mechanism(s), remains unknown. In this study, we focused on zinc transporters

Indexed as

Cation Transport ProteinsFertilizationOocytesZincAnimalsFemaleMiceMice, KnockoutCation Transport ProteinsZincZIP10 protein, mousecell biologydevelopmental biologyembryo developmentfertilizationmammalsmousezinc homeostasiszinc spark

Identifiers

PMID41378776
PMCPMC12698087

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.