SynthesisPediatric nephrology (Berlin, Germany)2026
Systematic review of neuroimaging findings in children and young adults with chronic kidney disease.
Synthesis in Pediatric nephrology (Berlin, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed, 1 synthesis or guideline pooled it.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundChronic kidney disease (CKD) is associated with poorer neurocognitive outcomes. Neuroimaging studies have been mostly undertaken in older adults. However, individuals under 25 are uniquely impacted due to concurrent brain development.
aimsThis systematic review explored neuroimaging in children and young adults with CKD aiming to characterize brain outcomes in paediatric CKD.
methodsA systematic search of MEDLINE Ovid, EMBASE and Cochrane databases was undertaken on October 10, 2024. Observational studies involving patients with CKD aged 0-25 years and having neuroimaging findings as a key outcome were included. Following quality assessment using the Newcastle-Ottawa scale, a narrative review was performed.
resultsSixteen studies were included: 737 individuals across studies. Smaller brain volumes were reported in three of five studies (with one contradictory). White matter integrity was impaired, even in patients with mild disease. The latter was associated with a lower intelligence quotient. Silent brain infarcts were identified in up to 79% of dialysis patients with associations with markers of bone disease, longer dialysis duration and haemodynamic instability. Brain regions involved in attention, executive functions and the resting-state network demonstrated abnormal connectivity that was associated with longer reactivity and a response time in visual memory task. Measures of anaemia were inversely associated with increased cerebral blood flow (CBF) which corresponded with poorer verbal memory.
conclusionNeurodevelopment is altered in paediatric CKD. Although a global mechanism for this remains unclear, it is evident that even early CKD is associated with increased risk of brain damage and cognitive deficits. Treatment methods and duration, disease severity and blood calcium and parathyroid concentrations were strongly associated with brain injury. Future work should prioritize longitudinal models of assessment with a focus on recruitment of uniform groups based on age, disease severity, aetiology and treatment to more clearly delineate the effects of disease on neurodevelopment.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.