Evidence map›Paper›PMID 41379219›Full record

ArticleActa neuropathologica2025

Confirmation of p-tau Ser356's association with Alzheimer's disease pathology and lowering in response to WZ4003 treatment in brain slice cultures. Reply to: "Phospho-tau Ser356 is mostly confined to pre-NFT neurons in Alzheimer's pathology".

Lewis W Taylor, Elizabeth M Simzer, Lauren F P Young, Kristján Holt, Tara L Spires-Jones, Claire S Durrant

Abstract readLetter
PubMed Publisher
In one paragraph

Article in Acta neuropathologica, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Lewis W TaylorInstitute for Neuroscience and Cardiovascular Research, 1 George Square, The University of Edinburgh, Edinburgh, UK.ORCID http://orcid.org/0009-0006-6014-3734
Elizabeth M SimzerInstitute for Neuroscience and Cardiovascular Research, 1 George Square, The University of Edinburgh, Edinburgh, UK.ORCID http://orcid.org/0000-0002-7043-1450
Lauren F P YoungInstitute for Neuroscience and Cardiovascular Research, 1 George Square, The University of Edinburgh, Edinburgh, UK.ORCID http://orcid.org/0009-0002-1612-1555
Kristján HoltInstitute for Neuroscience and Cardiovascular Research, 1 George Square, The University of Edinburgh, Edinburgh, UK.ORCID http://orcid.org/0000-0003-3903-6361
Tara L Spires-JonesInstitute for Neuroscience and Cardiovascular Research, 1 George Square, The University of Edinburgh, Edinburgh, UK.ORCID http://orcid.org/0000-0003-2530-0598
Claire S DurrantInstitute for Neuroscience and Cardiovascular Research, 1 George Square, The University of Edinburgh, Edinburgh, UK. claire.durrant@ed.ac.uk.ORCID http://orcid.org/0000-0001-7552-7358

Funding

Alzheimer's Society AS-PG-21-006Race Against Dementia RADF-2019a-001UK Dementia Research Institute UKDRI-Edin005
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Identifiers

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.