ArticleMolecular biology reports2025
Dual role of Curcumin and nano-formulations in radiotherapy: sensitizing cancer cells and protecting normal cells.
Article in Molecular biology reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- A Modern Odyssey of Prevention: Integrating Nutrition and Lifestyle in Radiation Mitigation- A Narrative Review.Dose-response : a publication of International Hormesis SocietyReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionCurcumin, the principal bioactive constituent of turmeric, demonstrates a bifunctional role in radiotherapy by enhancing the radiosensitivity of malignant cells while concurrently conferring protection to normal cells. Nevertheless, its clinical application is hindered by limited bioavailability. This investigation assesses the effectiveness of two innovative nano-formulations-namely nanomicelles and nanoniosomes-in augmenting curcumin's radiosensitizing and radioprotective properties. METHODS AND
resultsHuman colorectal carcinoma (HT-29) cells and human foreskin fibroblasts (HFF) were treated with bulk curcumin, nanomicelles, or nanoniosomes, followed by exposure to 6 MV X-ray radiation. Cellular viability, apoptotic induction, and clonogenic survival were evaluated through MTT assays, annexin V-propidium iodide staining, and colony formation assays, respectively. All curcumin formulations decreased cancer cell viability, with nanomicelles exhibiting a notably lower IC50 (20 µM) compared to nanoniosomes (135 µM) in HT-29 cells. Nanomicelles demonstrated dual functionality by sensitizing HT-29 cells to radiation-evidenced by a 40% reduction in survival fraction at 2 Gy (p < 0.01)-and protecting HFF cells from radiation-induced apoptosis, reducing apoptotic rates by 30% relative to controls. Conversely, nanoniosomes displayed cytotoxic effects without significant radioprotective activity.
conclusionThe findings indicate that nanomicelle-based curcumin formulations possess both radiosensitizing and radioprotective capabilities, whereas nanoniosomes exhibit cytotoxicity without conferring radioprotection.
Indexed as
Identifiers
41379239What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.