ArticlePloS one2025
Acute kidney injury and chronic kidney disease in Chile: Temporal trends in hospitalization rates from 2010 to 2019.
Article in PloS one, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundKidney diseases pose considerable challenges to health systems affecting millions of people worldwide. In Latin America there are limited epidemiological studies on these conditions.
objectiveThis study aimed to describe the national age-adjusted hospitalization trends for acute kidney injury (AKI) and chronic kidney disease (CKD) in the Chilean population.
methodsWe conducted a retrospective study using a secondary data from hospitalized cases diagnosed with AKI and CKD in Chile, from 2010 to 2019. Age-adjusted hospitalization rates and JoinPoint regression analysis were performed.
resultsBetween 2010 and 2019, 26,715 hospitalizations of patients diagnosed with AKI and 99,816 patients with CKD were recorded. Nationally, long-term trends in age-adjusted hospitalization rates for AKI increased by 9.1% annually (95% CI: 8.0 to 10.5), whereas CKD hospitalization rates declined by 4.35% (95% CI: -5.76 to -2.99) over the study period. Short-term trends in AKI hospitalization rates showed initial declines in Maule between 2010-2017 (-7.97%, 95% CI: -13.63 to -6.04) followed by increases from 2017 to 2019 (8.45%, 95% CI: -4.08 to 17.66), whereas Valparaíso (7.2%, 95% CI: 5.2 to 9.5) experienced steady growth. Although CKD rates generally declined, central regions such as O'Higgins and Maule showed increases between 2016-2019 (10.6%, 95% CI: 5.1 to 19.9) and 2017-2019 (8.5%, 95% CI: -4.1 to 17.7), respectively. CONCLUSION/
interpretationThis study highlights AKI as a growing public health challenge nationwide, with increasing hospitalization rates. At the same time, CKD hospitalizations show a reduction, although regional disparities remain a concern. Efforts should focus on enhanced integral surveillance to address these trends effectively across the country.
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