Evidence map›Paper›PMID 41379997›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2025

Fluoride triggers lysis in

Aditya Banerjee, Sophie Pickelner, Faith Smith, Livia M A Tenuta, Randy B Stockbridge

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Aditya BanerjeeDepartment of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, MI 48109.ORCID 0000-0003-0365-5582
Sophie PickelnerDepartment of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, MI 48109.ORCID 0009-0004-5557-7947
Faith SmithDepartment of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, MI 48109.
Livia M A TenutaDepartment of Cariology, Restorative Sciences & Endodontics, School of Dentistry, University of Michigan, Ann Arbor, MI 48109.
Randy B StockbridgeDepartment of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, MI 48109.ORCID 0000-0001-8848-3032

Funding

A multiscale approach to develop and apply fluoride efflux inhibitors to reverse oral dysbiosis and eliminate early childhood cariesRM1DE034220 · NIDCR · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Randy B. Stockbridge, Livia Maria Andalo Tenuta · 2024 to 2026
$3.3M
Orbitrap Fusion Lumos ETD with IRMPD for UM Chemistry MS Facility ExpansionS10OD021619 · OD · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI HAKANSSON, KRISTINA · 2016 to 2016
$1.1M
NIDCR NIH HHS RM1 DE034220NIH HHS S10 OD021619
6 · The paper itself

Abstract

Fluoride has long been known to possess antimicrobial properties. For many bacteria, the toxic effects of fluoride are reversible. However, fluoride has also been shown to trigger lysis and cell death in many other diverse bacterial species, including dental pathogens. The underlying molecular mechanisms responsible for fluoride-induced cell lysis have not been established. Using

Indexed as

BacteriolysisEndopeptidase ClpFluoridesStreptococcus mutansBacterial ProteinsBacteriocinsCell WallGene Expression Regulation, BacterialSigma FactorTranscription FactorsBacterial ProteinsBacteriocinsComX protein, StreptococcusEndopeptidase ClpFluoridesSigma FactorTranscription FactorsautolysiscariesClp proteasesigma factorstress response

Identifiers

PMID41379997
PMCPMC12700350

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.