ArticleCell genomics2026
The physical chemistry of interphase loop extrusion.
Article in Cell genomics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Mechanisms and functional implications of long-range enhancer-dependent gene regulation.Nature genetics · 2026Review
- Cohesin bridging as a physical principle of enhancer-promoter communication.bioRxiv : the preprint server for biology · 2026Article
- Cohesin cofactor dosage sets the rate of loop extrusion, rendering genome folding tunable yet vulnerable to genetic disruption.Molecular cell · 2026Article
- Cohesin extrudes chromatin loop unidirectionally through two modes of mechanisms in human cells.bioRxiv : the preprint server for biology · 2026Article
- A first-principles quantitative framework for how cohesin regulators shape chromatin loop extrusion.Cell genomics · 2026Article
- Dosage sensitivity of the loop extrusion rate confers tunability to genome folding while creating vulnerability to genetic disruption.bioRxiv : the preprint server for biology · 2025Article
- RETRACTED: Kinetic organization of the genome revealed by ultraresolution multiscale live imaging.Science (New York, N.Y.) · 2025Article
- Dynamic barriers modulate cohesin positioning and genome folding at fixed occupancy.Genome research · 2025Article
- Dynamic barriers modulate cohesin positioning and genome folding at fixed occupancy.bioRxiv : the preprint server for biology · 2024Article
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2 authors.
Funding
Abstract
Cohesin drives genome organization via loop extrusion, orchestrated by the dynamic exchange of multiple essential accessory proteins. Although these regulators bind the core cohesin complex only transiently, their disruption can dramatically alter loop-extrusion dynamics and chromosome morphology. Still, a quantitative theory of cohesin regulation and its interplay with genome folding is still elusive. Here, we derive a chemical-reaction network model of loop-extrusion regulation from first principles that is fully specified by available in vivo measurements. This "bursty extrusion model" untangles the distinct roles of regulators, whose exchange coincides with intermittent periods of motor activity. By incorporating bursty extrusion in polymer simulations, we reveal how variations in regulatory protein abundance can alter chromatin architecture across length and timescales. Our results are corroborated by in vivo and in vitro observations, bridging the gap between cohesin-regulator dynamics at the molecular scale and their genome-wide consequences on chromosome organization.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.