ArticleThe Journal of international medical research2025
Network toxicology and multiomics reveal bisphenol A-mediated immune evasion in breast cancer.
Article in The Journal of international medical research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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3 authors.
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Abstract
ObjectiveTo test whether exposure to bisphenol A is related to immune modulation and prognosis in breast cancer using an integrative framework.MethodsBisphenol A targets from toxicology resources were intersected with breast cancer genes. Protein-protein interaction networks were constructed, and hubs were prioritized by centrality. Survival was evaluated in The Cancer Genome Atlas breast cancer cohort using Cox and Kaplan-Meier analyses. The tumor microenvironment was profiled using ESTIMATE scores and CIBERSORT deconvolution. Consistency was examined in the independent METABRIC cohort. Docking was used to estimate bisphenol A-protein binding free energies.ResultsFiltering converged on four immunoregulatory genes-
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