Evidence map›Paper›PMID 41381272›Full record

ArticleSurgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery2026

Impact of preoperative and postoperative anti-obesity medications on early postoperative body mass index reduction after sleeve gastrectomy in pediatrics.

Alaina P Vidmar, My H Vu, Matthew J Martin, Aimee G Kim, Stuart A Abel, Harry J Wong, Kamran Samakar

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Article in Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Alaina P VidmarChildren's Hospital Los Angeles and Keck School of Medicine of USC, Department of Pediatrics, Center for Endocrinology, Diabetes and Metabolism, Los Angeles, California. Electronic address: avidmar@chla.usc.edu.
My H VuChildren's Hospital Los Angeles and The Saban Research Institute Biostatistics Core, Los Angeles, California.
Matthew J MartinChildren's Hospital Los Angeles and Keck School of Medicine of USC, Department of Surgery, Division of Pediatric Surgery, Los Angeles, California; Division of Upper Gastrointestinal and General Surgery, Department of Surgery, Keck Medical Center of University of Southern California, Los Angeles, California.
Aimee G KimChildren's Hospital Los Angeles and Keck School of Medicine of USC, Department of Surgery, Division of Pediatric Surgery, Los Angeles, California.
Stuart A AbelChildren's Hospital Los Angeles and Keck School of Medicine of USC, Department of Surgery, Division of Pediatric Surgery, Los Angeles, California; Division of Upper Gastrointestinal and General Surgery, Department of Surgery, Keck Medical Center of University of Southern California, Los Angeles, California.
Harry J WongChildren's Hospital Los Angeles and Keck School of Medicine of USC, Department of Surgery, Division of Pediatric Surgery, Los Angeles, California; Division of Upper Gastrointestinal and General Surgery, Department of Surgery, Keck Medical Center of University of Southern California, Los Angeles, California.
Kamran SamakarChildren's Hospital Los Angeles and Keck School of Medicine of USC, Department of Surgery, Division of Pediatric Surgery, Los Angeles, California; Division of Upper Gastrointestinal and General Surgery, Department of Surgery, Keck Medical Center of University of Southern California, Los Angeles, California.

Funding

Impact of Meal Timing on Glycemic Profiles in Adolescents with Type 2 DiabetesK23DK134801 · NIDDK · CHILDREN'S HOSPITAL OF LOS ANGELES · PI Alaina P Vidmar · 2023 to 2026
$674k
NIDDK NIH HHS K23 DK134801
6 · The paper itself

Abstract

backgroundAntio-besity medications (OMs) are increasingly used in youth before and after metabolic and bariatric surgery (MBS), but their impact on surgical outcomes remains unclear.

objectivesThis study examined whether perioperative OM exposure affects early postoperative body mass index (BMI) reduction in youth undergoing sleeve gastrectomy (SG), and whether presurgery OM response influences outcomes.

settingPediatric MBS program at a free-standing, tertiary care, safety-net children's hospital.

methodsA retrospective review was conducted of youth (age 7-21) who underwent SG from November 2023 to March 2025. Youth were stratified based on perioperative OM use, defined as OM use for at least 3 months prior to surgery (n = 74). Among these 74 youth, 47 (64%) resumed OM use within 6 months postoperatively. This group was compared to youth with no OM exposure either before or after SG (n = 20). Primary outcomes were percent change in BMI (%BMI), percent excess BMI loss (% EBMIL), and percent total weight loss (% TWL) at 1-, 2-, and 3-months postsurgery. Secondary outcomes included 90-day postoperative safety and eating behavior changes. A secondary analysis compared "high responders" to OM (>5% BMI loss pre-SG, n = 23) versus "low responders" (≤5%, n = 51). Mixed-effects models adjusted for BMI at consult, age, and time between medical weight management and surgery date.

resultsAmong 94 youth (mean age 16.5 ± 2.3 years; BMI 50.1 ± 9.7 kg/m

conclusionsPerioperative OM use alone did not predict short-term weight loss after SG, but high OM responders before surgery had greater benefit. Further research is needed to optimize OM-MBS integration in youth.

Indexed as

Anti-Obesity AgentsBariatric SurgeryGastrectomyObesity, MorbidPediatric ObesityAdolescentBody Mass IndexChildFemaleHumansMalePostoperative CarePostoperative PeriodPreoperative CareRetrospective StudiesTreatment OutcomeAnti-Obesity AgentsAnti-obesity medicationsGlucagon-like-1-peptide agonistsMetabolic and bariatric surgeryPediatric obesitySemaglutide

Identifiers

PMID41381272
PMCPMC13491681

What Socratic holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.