Evidence mapPaperPMID 41382017Full record

SynthesisBMC public health2025

Global prevalence of multimorbidity among people living with type 2 diabetes: a systematic review and meta-analysis.

Yohannes Mulu Ferede, Kerstin Erlandsson, Mignote Hailu Gebrie, Debrework Tesgera Beshah, Osman Yimer Mohammed, Abere Woretaw Azagew, Margareta Westerbotn

Abstract readSystematic ReviewMeta-Analysis
In one paragraph

Synthesis in BMC public health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Yohannes Mulu FeredeDepartment of Medical Nursing, School of Nursing, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia. yohannesmulu50@gmail.com.
Kerstin ErlandssonSchool of Health and Welfare, Dalarna University, Falun, Sweden.
Mignote Hailu GebrieSchool of Nursing, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.
Debrework Tesgera BeshahSchool of Nursing, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.
Osman Yimer MohammedDepartment of Midwifery, School of Nursing and Midwifery, Asrat Woldeyes Health Science Campus, Debre Berhan University, Debre Berhan, Ethiopia.
Abere Woretaw AzagewDepartment of Medical Nursing, School of Nursing, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.
Margareta WesterbotnInstitution of Nursing Science, Sophiahemmet University, Stockholm, Sweden.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMultimorbidity is increasing over time and causes a major global health challenge among individuals with type 2 diabetes (T2D). The growing prevalence of multimorbidity coupled with its complex management leads to a significant concern for the healthcare system. Evidence of existing studies on multimorbidity showed inconsistencies across different regions in the world. This study aimed to summarize and estimate the pooled global prevalence of multimorbidity and its associated factors among patients with T2D.

methodsA systematic review and meta-analysis were conducted, including studies up to January 2025. PubMed, HINARI, CINAHL/EBSCO, the Cochrane Library, ProQuest, Google Scholar, and Google were used to search studies. The quality of the selected articles was evaluated using the Joanna Briggs Institute (JBI) checklist. The pooled prevalence was estimated using a random effect model with a 95% confidence interval (CI), while a fixed effect model was used to assess the pooled adjusted odds ratios (AORs) for the exposure variables. Heterogeneity was assessed using I² statistics and Cochran’s Q test (p-value). Subgroup analysis and meta-regression were used to identify the sources of variation. Publication bias was assessed using a funnel plot and Egger’s test (p-value < 0.05).

resultsIn this review, a total of 32 studies and 2,934,500 participants were included. The pooled global prevalence of multimorbidity among T2D was 83.17%, concordant conditions (related to T2D) was 50.21%, discordant conditions (unrelated to T2D) was 47.24%, and combined conditions (having both chronic conditions) was 58.90%. Age 40–59 years (AOR = 2.36, 95% CI: 1.17–3.55), being retired (AOR = 1.31, 95% CI: 0.96–1.66), non-formal education (AOR = 2.93, 95% CI: 1.44–4.42), being widowed (AOR = 2.00, 95% CI: 1.04–2.96), and being a current smoker (AOR = 2.33, 95% CI: 1.16–3.50) were the predictors of multimorbidity. Being an urban resident (AOR: 1.69, 95% CI: 0.95–2.44) was associated with concordant chronic conditions.

conclusionsMultimorbidity is highly prevalent among type 2 diabetes, emphasizing a major public health challenge. It is important to develop a well-designed and comprehensive strategy to enhance the prevention and management of multimorbidity. Particular emphasis should be given to older adults, people who have a low level of education, retired individuals, smokers, widowed individuals, and people living in urban residences.

trial registrationPROSPERO-CRD42025639310. Registered on January 16/2025.

Indexed as

Diabetes Mellitus, Type 2Global HealthMultimorbidityHumansPrevalenceConcordantDiscordantGlobalMultimorbidityT2D

Identifiers

PMID41382017
PMCPMC12802173

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.