Evidence map›Paper›PMID 41382056›Full record

Observational studyBMC gastroenterology2025

Clinical significance of the S204 phosphorylation of the Smad3 protein in combination with Ki67 for the metastasis and prognosis of gastric cancer.

Yi-Hui Kang, Ren-Sheng Chen, Qing Hu, Hong-Tao Sun, Pei Guo, Shi-Lin Lv, Ling-Yu Luo, De-Qiang Huang

Abstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in BMC gastroenterology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Yi-Hui KangDepartment of Gastroenterology, Jiangxi Provincial Key Laboratory of Digestive Diseases, Jiangxi Clinical Research Center for Gastroenterology, Digestive Disease Hospital, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, China.
Ren-Sheng ChenDepartment of Pathology, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi Province, 330006, China.
Qing HuDepartment of Gastroenterology, Jiangxi Provincial Key Laboratory of Digestive Diseases, Jiangxi Clinical Research Center for Gastroenterology, Digestive Disease Hospital, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, China.
Hong-Tao SunDepartment of Gastroenterology, Jiangxi Provincial Key Laboratory of Digestive Diseases, Jiangxi Clinical Research Center for Gastroenterology, Digestive Disease Hospital, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, China.
Pei GuoDepartment of Pathology, Shenzhen Hospital of Southern Medical University, Shenzhen, China.
Shi-Lin LvDepartment of Gastroenterology, Jiangxi Provincial Key Laboratory of Digestive Diseases, Jiangxi Clinical Research Center for Gastroenterology, Digestive Disease Hospital, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, China.
Ling-Yu LuoDepartment of Gastroenterology, Jiangxi Provincial Key Laboratory of Digestive Diseases, Jiangxi Clinical Research Center for Gastroenterology, Digestive Disease Hospital, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, China.
De-Qiang HuangDepartment of Gastroenterology, Jiangxi Provincial Key Laboratory of Digestive Diseases, Jiangxi Clinical Research Center for Gastroenterology, Digestive Disease Hospital, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, China. hdq0515@ncu.edu.cn.

Funding

Nature Science Foundation of Jiangxi province of China 20232BAB206086, 20192BAB205072, 20203BBGL73206, 2017BCB23086, 2017BAB205062, 2018BAB205050the National Nature Science Foundation of China Grants 82360517, 82060450, 81460374, 31460304
6 · The paper itself

Abstract

aimThe purpose of this study is to explore the prognostic evaluation value of Ki67 and pSmad3L (S204) for gastric cancer (GC) patients by jointly analyzing their expression levels in GC tissues.

methodsThis single-center observational study enrolled 98 patients with pathologically confirmed GC, collecting 82 paired samples of tumor and adjacent normal tissues. Immunohistochemistry was utilized to detect the expression levels of CD133, E-cad, Ki67, and pSmad3L (S204). Pearson correlation coefficients were calculated to assess inter-protein relationships, while chi-square tests evaluated associations with clinicopathological parameters. Kaplan-Meier analysis generated survival curves, and univariate and multivariate COX regression analyses were conducted to establish a prognostic prediction model.

resultsCompared with adjacent normal tissues, the expressions of CD133, E-cad, and Ki67 were upregulated in GC tissues. The high expression of CD133 was associated with the tumor type, and the high expression of Ki67 was related to tumor grading and distant metastasis. Multivariate analysis showed that the depth of invasion, lymph node metastasis, Ki67, and pSmad3L (S204) were independent prognostic risk factors for GC patients. The co-expression of high levels of Ki67 and pSmad3L (S204) predicted a poor prognosis.

conclusionHigh expression of Ki67 and high expression of pSmad3L(S204) are independent risk factors for the prognosis of patients with GC, and the combined analysis of Ki67 and pSmad3L(S204) can help to improve the risk prediction.

Indexed as

Ki-67 AntigenSmad3 ProteinStomach NeoplasmsAC133 AntigenAgedAntigens, CDBiomarkers, TumorClinical RelevanceFemaleHumansImmunohistochemistryKaplan-Meier EstimateLymphatic MetastasisMaleMiddle AgedNeoplasm MetastasisAC133 AntigenAntigens, CDBiomarkers, TumorKi-67 AntigenMKI67 protein, humanPROM1 protein, humanSmad3 ProteinSMAD3 protein, humanCD133E-cadGastric cancerKi67PrognosisPSmad3L(S204)

Identifiers

PMID41382056
PMCPMC12817876

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.