Evidence map›Paper›PMID 41382143›Full record

ArticleParticle and fibre toxicology2025

Sleep disruption from inhalation of biomass smoke: a basis for coincident hypertension?

K M Rentschler, W Kyle Martin, W Oshiro, M C Schladweiler, T W Jackson, W E Cascio, U P Kodavanti, P A Evansky, C Lambright, R Strader and 11 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Particle and fibre toxicology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

K M Rentschler *Oak Ridge Institute for Science and Education, Oak Ridge, TN, 37830, USA.
W Kyle Martin *Oak Ridge Institute for Science and Education, Oak Ridge, TN, 37830, USA.
W OshiroCenter for Public Health and Environmental Assessment, Office of Research and Development, US Environmental Protection Agency, 109 T.W. Alexander Drive, B105-02, Research Triangle Park, NC, 27711, USA.
M C SchladweilerCenter for Public Health and Environmental Assessment, Office of Research and Development, US Environmental Protection Agency, 109 T.W. Alexander Drive, B105-02, Research Triangle Park, NC, 27711, USA.
T W JacksonCenter for Public Health and Environmental Assessment, Office of Research and Development, US Environmental Protection Agency, 109 T.W. Alexander Drive, B105-02, Research Triangle Park, NC, 27711, USA.
W E CascioCenter for Public Health and Environmental Assessment, Office of Research and Development, US Environmental Protection Agency, 109 T.W. Alexander Drive, B105-02, Research Triangle Park, NC, 27711, USA.
U P KodavantiCenter for Public Health and Environmental Assessment, Office of Research and Development, US Environmental Protection Agency, 109 T.W. Alexander Drive, B105-02, Research Triangle Park, NC, 27711, USA.
P A EvanskyCenter for Public Health and Environmental Assessment, Office of Research and Development, US Environmental Protection Agency, 109 T.W. Alexander Drive, B105-02, Research Triangle Park, NC, 27711, USA.
C LambrightCenter for Public Health and Environmental Assessment, Office of Research and Development, US Environmental Protection Agency, 109 T.W. Alexander Drive, B105-02, Research Triangle Park, NC, 27711, USA.
R StraderOak Ridge Institute for Science and Education, Oak Ridge, TN, 37830, USA.
J ConleyCenter for Public Health and Environmental Assessment, Office of Research and Development, US Environmental Protection Agency, 109 T.W. Alexander Drive, B105-02, Research Triangle Park, NC, 27711, USA.
W WilliamsCenter for Public Health and Environmental Assessment, Office of Research and Development, US Environmental Protection Agency, 109 T.W. Alexander Drive, B105-02, Research Triangle Park, NC, 27711, USA.
D FreebornCenter for Public Health and Environmental Assessment, Office of Research and Development, US Environmental Protection Agency, 109 T.W. Alexander Drive, B105-02, Research Triangle Park, NC, 27711, USA.
C N MillerCenter for Public Health and Environmental Assessment, Office of Research and Development, US Environmental Protection Agency, 109 T.W. Alexander Drive, B105-02, Research Triangle Park, NC, 27711, USA.
R GrindstaffCenter for Public Health and Environmental Assessment, Office of Research and Development, US Environmental Protection Agency, 109 T.W. Alexander Drive, B105-02, Research Triangle Park, NC, 27711, USA.
M MonseesOak Ridge Institute for Science and Education, Oak Ridge, TN, 37830, USA.
A A LewisOak Ridge Institute for Science and Education, Oak Ridge, TN, 37830, USA.
D W HerrCenter for Public Health and Environmental Assessment, Office of Research and Development, US Environmental Protection Agency, 109 T.W. Alexander Drive, B105-02, Research Triangle Park, NC, 27711, USA.
P R S KodavantiCenter for Public Health and Environmental Assessment, Office of Research and Development, US Environmental Protection Agency, 109 T.W. Alexander Drive, B105-02, Research Triangle Park, NC, 27711, USA.
M S HazariCenter for Public Health and Environmental Assessment, Office of Research and Development, US Environmental Protection Agency, 109 T.W. Alexander Drive, B105-02, Research Triangle Park, NC, 27711, USA.
A K FarrajCenter for Public Health and Environmental Assessment, Office of Research and Development, US Environmental Protection Agency, 109 T.W. Alexander Drive, B105-02, Research Triangle Park, NC, 27711, USA. farraj.aimen@epa.gov.

Funding

Office of Research and Development, U.S. Environmental Protection Agency
6 · The paper itself

Abstract

backgroundExposure to air pollution including contemporary sources like wildland fire smoke worsens cardiovascular outcomes. Although several mechanisms for these effects have been postulated, one underexplored impact of inhaled air pollution that may mediate adverse health outcomes is sleep disruption, which is an independent risk factor for cardiovascular morbidity and a trigger of multiple biological pathways linked to disease. The purpose of this study was to determine whether cardiovascular responses to air pollution, especially excursions in blood pressure, are associated with contemporaneous changes in sleep status. Three-month old male and female Sprague Dawley rats were implanted with radiotelemetry devices that simultaneously measured aortic blood pressure and the electroencephalogram (EEG), which was used to quantify sleep quality and depth. Heart rate variability (HRV), an indirect measure of autonomic tone, and blood pressure variability (BPV) were assessed from the blood pressure signal. Rats were monitored before, during and after a single 1-hour whole body inhalation exposure to filtered air or tube furnace-generated eucalyptus smoke (632-904 µg/m

resultsSmoke exposure caused increases in heart rate, blood pressure, BPV, and HRV markers of sympathetic tone and concomitant disruption in several sleep parameters including slow-wave and paradoxical sleep, and wake duration to varying degrees in male and female rats relative to sex-matched filtered air controls during exposure.After exposure, smoke caused decreases in cardiovascular function and sympathetic tone that again varied by sex, although both males and females had rebound increases in sleep drive. Finally, although there were some minor sex differences, the cardiovascular and sleep responses in the smoke groups were largely more strongly correlated with one another and with HRV markers of sympathetic tone relative to responses in the respective filtered air groups.

conclusionsThese findings suggest that some of the cardiovascular responses to air pollution, including hypertension, may be related to perturbations in sleep and associated changes in autonomic tone.

Indexed as

Air PollutantsBiomassHypertensionInhalation ExposureParticulate MatterSleepSleep Wake DisordersSmokeAnimalsBlood PressureElectroencephalographyFemaleHeart RateMaleRatsRats, Sprague-DawleyAir PollutantsParticulate MatterSmokeAir pollutionAutonomic nervous systemBiomass smokeBlood pressureCardiovascular healthElectroencephalogramEucalyptusSleepWildfires

Identifiers

PMID41382143
PMCPMC12696922

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.