ArticleLipids in health and disease2025
Phospholipid composition in small airway lining fluid among tunnel construction workers exposed to respirable crystalline silica.
Article in Lipids in health and disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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9 authors.
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Abstract
objectiveTo explore if the phospholipid composition in the small airway lining fluid differed between a group of tunnel construction workers exposed to respirable crystalline silica (RCS) and a reference group.
methodsIn total, 19 healthy, non-smoking workers under exposure to RCS and 21 unexposed referents from the same construction site were included. The participants underwent a health examination including lung function measurements and collection of exhaled particles (PEx) using the Particles in exhaled air (PExA) method. Analysis of PEx included determination of lipids. In total, 95 lipid species, primarily phospholipids, were determined. Non-parametric analyses (Wilcoxon rank-sum test and quantile regression), principal component analysis (PCA) and orthogonal partial least squares discriminant analysis (OPLS-DA) were used for data analysis.
resultsA difference in mol% of phospholipids between the RCS exposed tunnel construction workers and unexposed referents was observed. On lipid class level there was a higher mol% of sphingomyelin (SM) species among exposed workers compared to referents. Regarding single phospholipid species, higher mol % of phosphatidylcholine (PC) and phosphatidylglycerol (PG) species containing diacyl chains with 18:2 (linoleic acid) and 20:4 (arachidonic acid) fatty acid components were observed in the exposed group. Additionally, lower mol% of saturated PC species were observed among the exposed.
conclusionsDifferences in phospholipid composition in the small airway lining fluid between workers exposed to RCS and a reference group were observed. This indicates a possible impact of RCS exposure on phospholipids in the small airways. However, whether these are linked to health effects is currently not known.
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