ArticleEuropean journal of medical research2025
Association between clinical parameters and severity of acute pulmonary embolism: a retrospective study.
Article in European journal of medical research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Methylation in the TAC1 Gene Promoter Is Associated with the Transition from Acute Pulmonary Embolism to Chronic Thromboembolic Pulmonary Hypertension.International journal of molecular sciences · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
backgroundAcute pulmonary embolism (APE) is the third most frequent life-threatening cardiovascular disease. Which clinical parameters correlate with APE severity are still unclear. This study aimed to investigate the association between clinical parameters and APE severity, and to detect the parameters that could predict severe (intermediate high- and high-risk) APE.
methodsClinical data from 612 hospitalized APE patients from two centres in China were collected. Univariate or multivariate ordinal logistic regression analyses were used to detect the relationship between clinical parameters and APE severity. Receiver-operating characteristic (ROC) curves were used to calculate the predictive values of single or combined parameters in predicting severe APE or 30-day mortality in a discovery cohort (n = 368) and a validation cohort (n = 244).
resultsAge (odds ratio [OR], 1.462; 95% confidence interval [CI]: 1.241-1.723, P < 0.0001), coronary atherosclerotic heart disease (CAD) (OR, 3.103; 95% CI 1.946-4.950, P < 0.0001), total affected arteries (OR,1.365; 95%CI 1.201-1.551, P < 0.0001) and D-dimer (OR, 1.071; 95% CI 1.039-1.104, P < 0.0001) were independently correlated with APE severity. A combination of total affected arteries (TAA) more than 2, CAD, and D-dimer more than 2.99 mg/L represented the largest area under the curves (AUC = 0.860, sensitivity = 75.37%, specificity = 83.76%) in predicting severe APE. For 30-day mortality prediction, older than 77 years combined with TAA more than 2 showed an excellent performance in both the discovery cohort (AUC = 0.838, P < 0.0001) and validation cohort (AUC = 0.776, P < 0.001).
conclusionsPatients with CAD, more than 2 central affected arteries, and D-dimer more than 2.99 mg/L have an increased risk of developing severe APE. Patients older than 77 years with more than 2 central affected arteries suffer an increased risk of death within 30 days of APE.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.