Evidence map›Paper›PMID 41382292›Full record

ArticleBMC infectious diseases2025

Association between CYP2C19 gene polymorphisms and Helicobacter pylori infection in Hainan region.

Shimei Huang, Daya Zhang, Da Li, Chen Chen, Fan Zeng, Shiju Chen, Runxiang Chen, Xiaodong Zhang, Feihu Bai

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In one paragraph

Article in BMC infectious diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Shimei Huang *Graduate School, Hainan Medical University, Haikou, 571199, China.
Daya Zhang *Department of Gastroenterology, The Second Affiliated Hospital of Hainan Medical University, Yehai Avenue, #368, Longhua District, Haikou, Hainan Province, 570216, China.
Da LiGraduate School, Hainan Medical University, Haikou, 571199, China.
Chen ChenGraduate School, Hainan Medical University, Haikou, 571199, China.
Fan ZengGraduate School, Hainan Medical University, Haikou, 571199, China.
Shiju ChenGraduate School, Hainan Medical University, Haikou, 571199, China.
Runxiang ChenGraduate School, Hainan Medical University, Haikou, 571199, China.
Xiaodong ZhangGraduate School, Hainan Medical University, Haikou, 571199, China.
Feihu BaiDepartment of Gastroenterology, The Second Affiliated Hospital of Hainan Medical University, Yehai Avenue, #368, Longhua District, Haikou, Hainan Province, 570216, China. baifeihu_hy@163.com.ORCID https://orcid.org/0000-0002-1560-6131

Funding

Hainan Province Clinical Medical Center 2021818Hainan Provincial Health Industry Research Project 22A200078Hainan Provincial Postgraduate Innovation Research Project Qhyb2022-133The specific research fund of The Innovation Platform for Academicians of Hainan Province YSPTZX202313
6 · The paper itself

Abstract

objectiveThis study was to investigate CYP2C19 gene and their association with H. pylori infection in the region of Hainan.

methodsWe conducted CYP2C19 genotype analysis in Hainan. The genotyping technique employed was MALDI-TOF-MS and a subset of participants underwent the 14 C-UBT.

resultsThe frequencies of CYP2C19*1, CYP2C19*2, CYP2C19*3, and CYP2C19*17 were 63.6%, 30.83%, 4.79%, and 0.78%, respectively.The frequency of the rapid metabolism type was 1.3%, normal metabolic type was 40.9%, medium metabolic type was 44.3%, and poor metabolism type was 13.4%. The frequencies of the four alleles and eight genotypes were not diverse among cities, BMI, genders, and ethnic. There were no significant differences in the frequencies of alleles, genotypes, and metabolic phenotypes between the H. pylori positive and negative groups.

conclusionIn Hainan, China, the predominant CYP2C19 genotype is *1/*1, and the predominant metabolic type is the intermediate one. CYP2C19 gene polymorphisms are not associated with H. pylori infection.

Indexed as

Cytochrome P-450 CYP2C19Helicobacter InfectionsHelicobacter pyloriPolymorphism, GeneticAllelesChinaFemaleGene FrequencyGenetic Predisposition to DiseaseGenotypeHumansMaleSpectrometry, Mass, Matrix-Assisted Laser Desorption-IonizationCYP2C19 protein, humanCytochrome P-450 CYP2C19CYP2C19Hainan provinceH. pyloriPolymorphism

Identifiers

PMID41382292
PMCPMC12699915

What Socratic holds

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LicenceCC BY-NC-ND
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.