Evidence mapPaperPMID 41382384Full record

ReviewEuropean journal of heart failure2025

Pharmacologic pitfalls in heart failure: A guide to drugs that may cause or exacerbate heart failure. A European Journal of Heart Failure expert consensus document.

Amr Abdin, Johann Bauersachs, Magdy Abdelhamid, Suleman Aktaa, Hussam Al Ghorani, Antonio Bayes-Genis, Jan Biegus, Michael Böhm, Javed Butler, Nicolas Girerd and 7 more

Abstract readConsensus StatementReview
In one paragraph

Review in European journal of heart failure, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Amr AbdinInternal Medicine Clinic III, Cardiology, Angiology and Intensive Care Medicine, Saarland University Hospital, Homburg/Saar, Germany.
Johann BauersachsDepartment of Cardiology and Angiology, Hannover Medical School, Hannover, Germany.
Magdy AbdelhamidFaculty of Medicine, Kasr Al Ainy, Cardiology Department, Cairo University, Giza, Egypt.
Suleman AktaaDepartment of Cardiology, St. Paul's Hospital, Vancouver, BC, Canada.
Hussam Al GhoraniInternal Medicine Clinic III, Cardiology, Angiology and Intensive Care Medicine, Saarland University Hospital, Homburg/Saar, Germany.
Antonio Bayes-GenisUniversity Hospital Germans Trias and Pujol, Badalona, Spain.
Jan BiegusDepartment of Cardiology, Clinical Department of Intensive Cardiac Care, Wroclaw Medical University, Faculty of Medicine, Institute of Heart Diseases, Wroclaw, Poland.
Michael BöhmInternal Medicine Clinic III, Cardiology, Angiology and Intensive Care Medicine, Saarland University Hospital, Homburg/Saar, Germany.
Javed ButlerBaylor Scott and White Research Institute, Dallas, TX, USA.
Nicolas GirerdINSERM, CHU de Nancy, Université de Lorraine, and the CardioRenal Integration Clinical Investigation Center, Vandoeuvre-les-Nancy, France.
Marco MetraCardiology, ASST Spedali Civili and Department of Experimental and Applied Medicine, Institute of Cardiology, University of Brescia, Brescia, Italy.
Wilfried MullensDepartment of Cardiology, Ziekenhuis Oost-Limburg, Genk, Belgium.
Hadi SkouriDivision of Cardiology, Sheikh Shakhbout Medical City, Abu Dhabi, United Arab Emirates.
Muthiah VaduganathanCardiovascular Division, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Seif El HadidiRoyal College of Surgeons in Ireland, Dublin, Ireland.
Giuseppe M C RosanoDepartment of Human Sciences and Promotion of Quality of Life, San Raffaele Open University of Rome, Rome, Italy.
Gianluigi SavareseDepartment of Clinical Science and Education, Södersjukhuset; Karolinska Institutet, Stockholm, Sweden.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Heart failure (HF) exerts a global health burden, often complicated by polypharmacy due to the frequent coexistence of cardiovascular and non-cardiovascular comorbidities. While guideline-directed medical therapy and devices have significantly improved outcomes, a range of commonly prescribed medications may inadvertently worsen HF or precipitate decompensation. This expert consensus statement provides a comprehensive overview of drugs known to cause or exacerbate HF, offering practical guidance for clinicians to identify and avoid harmful pharmacologic exposures in this vulnerable population. The review examines the pathophysiological mechanisms, clinical evidence, and guideline-based recommendations for several drug classes, including antidiabetic agents (e.g. thiazolidinediones, dipeptidyl peptidase-4 inhibitors), antiarrhythmics (particularly Class I and III), calcium channel blockers, non-steroidal anti-inflammatory drugs, antifungals (e.g. itraconazole, amphotericin B), macrolide antibiotics, antihypertensives (e.g. α

Indexed as

Heart FailureHumansHypoglycemic AgentsPolypharmacyHypoglycemic AgentsDrugsHarmfulHeart failureInteractionManagement

Identifiers

PMID41382384
PMCPMC12803569

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.