SynthesisFrontiers in neurology2025
Inflammatory biomarkers in cerebral venous thrombosis versus ischemic stroke: a network meta-analysis.
Synthesis in Frontiers in neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
- Erratum issued
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: In cerebrovascular diseases (CVD), the management strategies for ischemic stroke (IS) and cerebral venous thrombosis (CVT) have significant differences, but the underlying inflammation-driven mechanisms in these two conditions have not been fully translated into individualized intervention criteria. Methods: We searched PubMed, Embase, Web of Science and Cochrane Library through February 1, 2025, and included 18 eligible studies in a Bayesian network meta-analysis following PRISMA-NMA. The data were processed using Revman (version 5.4.1) and R (version 4.3.3). The Grading of Recommendations, Assessment, Development and Evaluation (GRADE) method was used to assess the quality of evidence. This study was registered in PROSPERO (CRD42024539498). Results: In total, 18 studies were included in the review. The results showed that acute-phase inflammatory markers were significantly elevated in both CVT and IS. CVT was associated with a relatively stronger systemic inflammatory response, while lymphocyte counts were reduced in both, suggesting a immunosuppressive phenomenon in cerebral thrombotic disease. This network Meta-Analysis showed that CRP (MD = 7.58, 95% CI: 2.48-14.09) and IL-6 (MD = 6.98, 95% CI: 2.75-11.44) were more significantly elevated in the acute phase in CVT patients than in IS patients, suggesting they could serve as key inflammatory markers for differentiating the two conditions. Conclusion: Inflammatory markers exhibit both specific differences and shared characteristics in CVT and IS. CRP and IL-6 were higher in CVT than in IS in Bayesian NMA, suggesting potential adjunctive markers for differential diagnosis; however, these findings are hypothesis-generating and require prospective validation, and neuroimaging remains the diagnostic gold standard. Systematic review registration: https://www.crd.york.ac.uk/PROSPERO/view/CRD42024539498, CRD42024539498.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.