ArticleFrontiers in neurology2025
Epilepsy-associated
Article in Frontiers in neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Biological Context-Informed and Population-Stratified Strategies Improve Genetic Diagnosis of CCDC22-Related Disorder.Genetics research · 2026Article
- Precision diagnosis ofFrontiers in genetics · 2026Article
- Toward precision medicine inFrontiers in neurologyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: The Methods: The dataset of pathogenic and control Result: A total of 27 missense variants which were classified as pathogenic or likely pathogenic were used as a positive set, and 57 missense variants were used as a negative set. The top tools in accuracy are MutPred2, ESM1b, AlphaMissense, and PROVEAN. In terms of the MCC and F score, the higher degree was observed in MutPred2 and AlphaMissense (MCC score >0.8). ClinPred, AlphaMissense, and BayesDel_addAF had a higher AUC score (AUC > 0.99). SIFT, SIFT4G, Polyphen2_HDIV, Polyphen2_HVAR, ClinPred, and AlphaMissense scores exhibited a distinct bimodal distribution. While scores from other predictors showed a wider distribution range. Conclusion: Our study highlights the significant variation in the performance of different
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.