ArticleNeuroprotection (Chichester, England)2024
Impact of neutrophil-to-lymphocyte ratio on the effect of hyperglycemia at admission on clinical outcomes after endovascular thrombectomy.
Article in Neuroprotection (Chichester, England), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.
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Who cites it
6 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Neutrophil-to-lymphocyte ratio as a predictor of prognosis in patients with spontaneous intracerebral hemorrhage: a systematic review and meta-analysis.Frontiers in neurology · 2025Pooled it
- Colchicine as an Adjunctive Therapy to Improve Ischemic Stroke Reperfusion Outcomes in Mice.CNS neuroscience & therapeutics · 2026Article
- Plasma vitamin D binding protein as the potential predictor of depressive disorder risk in breast cancer patients.Scientific reports · 2025Article
- Characteristics of Cerebral Autoregulation After Mechanical Thrombectomy and Its Relationship With Prognosis.CNS neuroscience & therapeutics · 2025Article
- Associations between blood systemic inflammatory markers and anxiety inFrontiers in psychiatry · 2025Article
- Impact of neutrophil-to-lymphocyte ratio on the effect of hyperglycemia at admission on clinical outcomes after endovascular thrombectomy.Neuroprotection (Chichester, England) · 2024Article
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Authors and funding
9 authors.
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Abstract
Background: The neutrophil-to-lymphocyte ratio (NLR) is highly associated with stress responses to acute disorders and may be useful for differentiating hyperglycemia after stroke that is induced by stress or other causes. This study aims to evaluate whether the NLR modifies the effect of hyperglycemia at admission on clinical outcome after thrombectomy. Methods: We retrospectively enrolled 343 patients that underwent endovascular thrombectomy for acute anterior circulation large-vessel occlusion between January 2019 and June 2022. NLR at admission was used to dichotomize patients into low-NLR and high-NLR groups according to its median value. The primary outcome was 90-day functional independence (modified Rankin Scale Score 0-2). Secondary outcomes were 24 h symptomatic intracranial hemorrhage and 90-day mortality. Results: Overall, hyperglycemia at admission decreased the likelihood of functional independence (adjusted odds ratio [OR]: 0.34, 95% confidence interval [95% CI]: 0.19-0.60, Conclusions: The NLR modified the detrimental effect of hyperglycemia at admission on functional independence after thrombectomy. Low-NLR patients with hyperglycemia were at a high risk of poor outcomes, and might more likely benefit from aggressive glucose-lowering treatment.
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