ArticleNanoscale advances2026
The anticancer effect of γ-irradiation synthesized selenium nanoparticles stabilized in β-glucan on HepG2 cell proliferation
Article in Nanoscale advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 authors.
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Abstract
The product of selenium nanoparticles (SeNPs) stabilized in water-soluble yeast β-glucan (SeNPs/β-glucan) was successfully synthesized by γ-ray irradiation on a scale of 3 liters per batch. The analysis results of its transmission electron microscopy (TEM) image showed that SeNPs in the product were spherical with an average actual particle size of about 63.3 nm, while dynamic light scattering (DLS) analyses indicated that the average hydrodynamic particle size of the product was about 93.5 nm with a narrow distribution and negative zeta potential value (-10.1 mV). In addition, the results also showed the hydrodynamic particle size and size distribution of the product slightly increased after storage for 60 days at 4 °C, whereas a more pronounced increase was observed when stored at room temperature (25 °C). Besides, the structural characteristics of SeNPs/β-glucan were also comprehensively analyzed using X-ray diffraction (XRD), Raman spectroscopy and Fourier transform infrared (FTIR) spectroscopy to confirm the crystal structure of the Se nanoparticles and their interaction with β-glucan molecules. The anticancer effects of SeNPs/β-glucan on the liver cancer cell line (HepG2) were also investigated and the obtained results demonstrated that SeNPs/β-glucan strongly inhibited the proliferation of HepG2 cells with a half maximal inhibitory concentration (IC
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