Evidence map›Paper›PMID 41384541›Full record

ReviewHuman vaccines & immunotherapeutics2025

Viral correlates of protection and the multifarious interactions of B and T cells.

H Cody Meissner, Peter B Gilbert, Derek Eisnor, Daniel N Wolfe

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Human vaccines & immunotherapeutics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Trial
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

H Cody MeissnerDepartment of Health and Human Services, Biomedical Advanced Research and Development Authority (BARDA), Administration for Strategic Preparedness and Response (ASPR), Washington, DC, USA.
Peter B GilbertVaccine & Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.
Derek EisnorDepartment of Health and Human Services, Biomedical Advanced Research and Development Authority (BARDA), Administration for Strategic Preparedness and Response (ASPR), Washington, DC, USA.
Daniel N WolfeDepartment of Health and Human Services, Biomedical Advanced Research and Development Authority (BARDA), Administration for Strategic Preparedness and Response (ASPR), Washington, DC, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Validated, reproducible methods to assess immunity to a specific virus following either infection or vaccination are important for understanding susceptibility to existing and emerging infectious diseases. Correlates of protection for a specific viral illness involve humoral and cellular responses that differ by pathogen and by the portal of entry into the host. Contemporary understanding of a correlate of protection primarily is based on serum neutralizing antibody concentrations because of difficulty in assaying the complex interactions of T cells. A more comprehensive understanding of susceptibility and protection is needed. The goal of this paper is to enumerate the multiple variables that complicate understanding of cellular contributions to the innate and adaptive immune responses.

Indexed as

B-LymphocytesT-LymphocytesVirus DiseasesAdaptive ImmunityAnimalsAntibodies, NeutralizingAntibodies, ViralHumansImmunity, CellularImmunity, HumoralImmunity, InnateAntibodies, NeutralizingAntibodies, Viraladaptive immunityB cellsCorrelates of protectioninnate immunityT cellsvaccines

Identifiers

PMID41384541
PMCPMC12710880

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.