Evidence map›Paper›PMID 41385040›Full record

ArticleMolecular neurobiology2025

Therapeutic Intervention of Corticospinal Tract Sprouting after Unilateral Traumatic Brain Injury via METTL1-Mediated tRNA m

Zhenpeng Li, An Jiang, Bengang Qin, Jintao Fang, Xubo Li, Fanbin Gu, Wenting He, Liwei Yan, Jiantao Yang, Canbin Zheng and 2 more

Abstract read
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In one paragraph

Article in Molecular neurobiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Zhenpeng Li *Department of Microsurgery, Orthopedic Trauma and Hand Surgery, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China.
An Jiang *Department of Microsurgery, Orthopedic Trauma and Hand Surgery, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China.
Bengang Qin *Department of Microsurgery, Orthopedic Trauma and Hand Surgery, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China.
Jintao FangDepartment of Microsurgery, Orthopedic Trauma and Hand Surgery, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China.
Xubo LiDepartment of Microsurgery, Orthopedic Trauma and Hand Surgery, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China.
Fanbin GuDepartment of Microsurgery, Orthopedic Trauma and Hand Surgery, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China.
Wenting HeDepartment of Microsurgery, Orthopedic Trauma and Hand Surgery, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China.
Liwei YanDepartment of Microsurgery, Orthopedic Trauma and Hand Surgery, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China.
Jiantao YangDepartment of Microsurgery, Orthopedic Trauma and Hand Surgery, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China.
Canbin ZhengDepartment of Microsurgery, Orthopedic Trauma and Hand Surgery, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China.
Qingtang ZhuDepartment of Microsurgery, Orthopedic Trauma and Hand Surgery, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China.
Honggang WangDepartment of Microsurgery, Orthopedic Trauma and Hand Surgery, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China. whongg@mail.sysu.edu.cn.

Funding

Featured Clinical Technique of Guangzhou C3230111National Key Research and Development Program of China 2022YFC2602800Natural Science Foundation of Guangdong Province 2022A1515012612
6 · The paper itself

Abstract

Corticospinal tracts (CST) from the contralateral side spontaneously sprouting into the denervated motor neurons in the impaired spinal hemicord allow the contralateral motor cortex to control the paralyzed limb, improving the impaired limb function after unilateral brain injury. However, the intrinsic potential for axon outgrowth in adults is limited, restricting the functional recovery through CST sprouting. While ribosomal RNA modification has been reported in regulating CST sprouting, the role of transfer RNA (tRNA) modifications remains unclear. Here, we investigated METTL1, the methyltransferase for tRNA m

Indexed as

Brain Injuries, TraumaticMethyltransferasesPyramidal TractsRNA, TransferAnimalsAxonsMaleMiceMice, Inbred C57BLNerve RegenerationRecovery of FunctionSignal TransductionTOR Serine-Threonine KinasesMethyltransferasesRNA, TransferTOR Serine-Threonine KinasesAxon outgrowthCorticospinal tract sproutingm7G modificationMETTL1Translation efficiencytRNAUnilateral brain injury

Identifiers

PMID41385040

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.