Evidence map›Paper›PMID 41385443›Full record

Trial reportPancreas2026

Internet-delivered Cognitive-Behavioral Intervention for Pain in Pediatric Acute Recurrent and Chronic Pancreatitis: A Multicenter Randomized Controlled Trial.

Tonya M Palermo, Rui Li, Chuan Zhou, Homer Aalfs, Gretchen Cress, Mark Lowe, Maisam Abu-El-Haija, Ankur Chugh, Elissa M Downs, Douglas S Fishman and 17 more

Abstract readRandomized Controlled TrialMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Pancreas, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

27 authors.

Tonya M PalermoCenter for Child Health, Behavior and Development, Seattle Children's Research Institute.ORCID 0000-0001-6036-6715
Rui LiCenter for Child Health, Behavior and Development, Seattle Children's Research Institute.
Chuan ZhouCenter for Child Health, Behavior and Development, Seattle Children's Research Institute.
Homer AalfsCenter for Child Health, Behavior and Development, Seattle Children's Research Institute.
Gretchen CressDepartment of Pediatrics, University of Iowa, Stead Family Children's Hospital, Iowa City, IA.
Mark LoweDepartments of Pediatrics, Gastroenterology, Hepatology & Nutrition, Washington University School of Medicine, St. Louis, MO.
Maisam Abu-El-HaijaCincinnati Children's Hospital Medical Center, and the Pediatric Department, College of Medicine, University of Cincinnati, Cincinnati, OH.
Ankur ChughDepartment of Pediatrics, Children's Wisconsin, Medical College of Wisconsin, Milwaukee, WI.
Elissa M DownsDepartment of Pediatrics, University of Minnesota Masonic Children's Hospital, Minneapolis, MN.
Douglas S FishmanDivision of Pediatric Gastroenterology, Hepatology, and Nutrition, Baylor College of Medicine and Texas Children's Hospital, Houston, TX.
Alvin Jay FreemanDivision of Pediatric Gastroenterology, Hepatology, and Nutrition, Nationwide Children's Hospital and The Ohio State College of Medicine, Columbus, OH.
Matthew J GieferDepartment of Pediatrics, Ochsner Hospital for Children, The University of Queensland, New Orleans, LA.
Tanja Y GonskaDepartment of Pediatrics, University of Toronto and Research Institute, The Hospital for Sick Children, Toronto, ON, Canada.
Sohail Z HusainDepartment of Pediatrics, Stanford University and Stanford Medicine Children's Health, Stanford, CA.
Douglas LindbladDepartment of Pediatrics, Children's Hospital of Pittsburgh of UPMC, Pittsburgh, PA.
Quin Y LiuDepartment of Pediatrics, Cedars-Sinai Medical Center, Los Angeles, CA.
Asim MaqboolDepartment of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, PA.
Jacob A MarkDepartment of Pediatrics - Gastroenterology, Hepatology and Nutrition, University of Colorado School of Medicine, Children's Hospital Colorado, Aurora, CO.
Brian A McFerronDivision of Pediatric Gastroenterology, Hepatology, and Nutrition, Riley Hospital for Children, Indiana University School of Medicine, Indianapolis, IN.
Megha S MehtaDepartment of Pediatrics, University of Texas Southwestern Medical School, Dallas.
Robert Adam NoelDepartment of Pediatrics, Baylor College of Medicine, San Antonio, TX.
Emily R PeritoDepartment of Pediatrics, University of California San Francisco, San Francisco, CA.
Fuchenchu WangDepartment of Biostatistics, The University of Texas, MD Anderson Cancer Center, Houston, TX.
Ying YuanDepartment of Biostatistics, The University of Texas, MD Anderson Cancer Center, Houston, TX.
Yuhua ZhengDepartment of Pediatrics, Children's Hospital Los Angeles, Los Angeles, CA.
Aliye UcDepartment of Pediatrics, University of Iowa, Stead Family Children's Hospital, Iowa City, IA.
Consortium for the Study of Chronic Pancreatitis, Diabetes, and Pancreatic Cancer (CPDPC)

Funding

Year 9 Administrative Supplement to INSPPIRE 2U01DK108334 · NIDDK · UNIVERSITY OF IOWA · PI MARK E. LOWE, Aliye Uc · 2015 to 2026
$10.5M
A Randomized Trial of a Web-based Non-Pharmacological Pain Intervention for Pediatric Chronic PancreatitisR01DK118752 · NIDDK · UNIVERSITY OF IOWA · PI PALERMO, TONYA M, UC, ALIYE · 2018 to 2022
$3.0M
NIDDK NIH HHS R01 DK118752NIDDK NIH HHS U01 DK108334
6 · The paper itself

Abstract

objectivesAbdominal pain is common and associated with high disease burden and health care costs in pediatric acute recurrent (ARP) and chronic pancreatitis (CP). Despite the effectiveness of psychological interventions in other abdominal pain populations, studies have not evaluated these interventions for pediatric pancreatitis pain. We evaluated the feasibility, acceptability, and preliminary efficacy of internet-delivered cognitive-behavioral therapy (CBT) for reducing pancreatitis-related abdominal pain and improving pain interference, anxiety, depression, activity limitations, and health-related quality of life.

methodsWe enrolled 90 adolescents (ages 10-19, 63% female) with ARP or CP and their parents into this randomized placebo-controlled multicenter trial from 15 INSPPIRE ( IN ternational S tudy Group of P ediatric P ancreatitis: I n search for a cu RE) centers or from the community. Participants were randomly assigned to internet-delivered CBT (WebMAP-CP; n=46) or internet-delivered pain education (WebED; n=44). Assessments were completed pretreatment, at 3 months, and 6 months posttreatment.

resultsHigh feasibility of intervention delivery was demonstrated by strong treatment engagement (>6 of 8 modules completed) in both groups. Treatment acceptability was higher in the WebMAP-CP group compared with WebED. There were no statistically significant between-group differences in pain or health outcomes.

conclusionsThis is the first trial to evaluate the feasibility, acceptability, and preliminary efficacy of internet-delivered CBT for pediatric pancreatitis pain, demonstrating strong feasibility and treatment acceptability. Due to under-enrollment, the trial had reduced statistical power. Future research with a larger sample may build on these findings.

Indexed as

Abdominal PainCognitive Behavioral TherapyInternetInternet-Based InterventionPain ManagementPancreatitisPancreatitis, ChronicAcute DiseaseAdolescentChildFeasibility StudiesFemaleHumansMalePain MeasurementQuality of Lifeacute recurrent pancreatitischildrenchronic pancreatitiscognitive-behavioral therapyinternet interventionpain

Identifiers

PMID41385443
PMCPMC13380129

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.