Evidence map›Paper›PMID 41385561›Full record

ArticleAmerican journal of physiology. Endocrinology and metabolism2026

RYGB induces vagal sensory neuropathy characterized by altered Glp1r expression and enhanced exendin-4 responsiveness in male mice.

Warda Merchant, Arely Tinajero, Adan Khan, Yi Chu, Sanaz Saleh, Dana Tasabehji, Donald A Morgan, Kevin W Williams, Kamal Rahmouni, Mohamad Mokadem and 1 more

Abstract read
In one paragraph

Article in American journal of physiology. Endocrinology and metabolism, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. ATF3-based peripheral neural tract tracing.Frontiers in neuroanatomy · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Warda MerchantDepartment of Internal Medicine and Center for Hypothalamic Research, UT Southwestern Medical Center, Dallas, Texas, United States.
Arely TinajeroDepartment of Internal Medicine and Center for Hypothalamic Research, UT Southwestern Medical Center, Dallas, Texas, United States.
Adan KhanDepartment of Internal Medicine and Center for Hypothalamic Research, UT Southwestern Medical Center, Dallas, Texas, United States.ORCID 0009-0004-7589-7905
Yi ChuDepartment of Internal Medicine, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, Iowa, United States.
Sanaz SalehDepartment of Internal Medicine, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, Iowa, United States.
Dana TasabehjiDepartment of Internal Medicine, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, Iowa, United States.
Donald A MorganDepartment of Neuroscience & Pharmacology, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, Iowa, United States.ORCID 0000-0003-3167-1643
Kevin W WilliamsDepartment of Internal Medicine and Center for Hypothalamic Research, UT Southwestern Medical Center, Dallas, Texas, United States.ORCID 0000-0002-8434-8658
Kamal RahmouniDepartment of Internal Medicine, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, Iowa, United States.ORCID 0000-0001-5136-6748
Mohamad MokademDepartment of Internal Medicine, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, Iowa, United States.ORCID 0000-0003-1402-580X
Laurent GautronDepartment of Internal Medicine and Center for Hypothalamic Research, UT Southwestern Medical Center, Dallas, Texas, United States.ORCID 0000-0003-3609-7441

Funding

Ventromedial Hypothalamic Regulation of Metabolic Changes Induced by ExerciseP01DK119130 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI ELMQUIST, JOEL K. · 2019 to 2023
$10.0M
UT Southwestern NORCP30DK127984 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI Jeffrey M Zigman · 2022 to 2026
$7.4M
Role of FGF21 Action in Hypothalamic Neurons in Obesity-Associated HypertensionR01HL162773 · NHLBI · UNIVERSITY OF IOWA · PI KAMAL RAHMOUNI · 2023 to 2026
$2.4M
Decoding Bariatric Surgery Outcomes through Activity and Transcriptional Analysis of Melanocortin NeuronsR01DK141541 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI KEVIN W WILLIAMS · 2025 to 2026
$1.6M
Neuronal Cilia in HypertensionR01HL172944 · NHLBI · UNIVERSITY OF IOWA · PI KAMAL RAHMOUNI · 2025 to 2026
$1.4M
BLRD VA I01 BX004249BLRD VA I01 BX004774BLRD VA IK6 BX006040HHS | National Institutes of Health (NIH) HL162773HHS | National Institutes of Health (NIH) HL172944HHS | National Institutes of Health (NIH) R01DK141541-01A1HHS | NIH | NIDDK | Division of Diabetes, Endocrinology, and Metabolic Diseases (DEM) P01DK119130NHLBI NIH HHS R01 HL162773NHLBI NIH HHS R01 HL172944NIDDK NIH HHS P01 DK119130NIDDK NIH HHS P30 DK127984NIDDK NIH HHS R01 DK141541University of Texas System (UT) TRC4066
6 · The paper itself

Abstract

The effects of Roux-en-Y gastric bypass (RYGB) on the gut-brain axis remain poorly understood. This study specifically explores phenotypic changes in vagal afferent neurons in male obese C57BL/6J mice following RYGB. Our results show that RYGB induced the expression of activating transcription factor 3 (

Indexed as

ExenatideGastric BypassGlucagon-Like Peptide-1 ReceptorPeripheral Nervous System DiseasesVagus NerveActivating Transcription Factor 3AnimalsGlucagon-Like Peptide-1 Receptor AgonistsMaleMiceMice, Inbred C57BLNodose GanglionObesityActivating Transcription Factor 3Atf3 protein, mouseExenatideGlp1r protein, mouseGlucagon-Like Peptide-1 ReceptorGlucagon-Like Peptide-1 Receptor Agonistsbariatric surgerymetabolismneuroplasticityvagus nerveweight loss

Identifiers

PMID41385561
PMCPMC12797217

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.