Evidence map›Paper›PMID 41385570›Full record

ArticleAmerican journal of physiology. Cell physiology2026

Skeletal muscle methylome-transcriptome disruptions during the onset and progression of colorectal cancer-induced cachexia.

Ana Regina Cabrera, Ronald G Jones, Eleanor R Shrems, Francielly Morena, Yuan Wen, Tyrone A Washington, Kevin A Murach, Nicholas P Greene

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of physiology. Cell physiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Ana Regina CabreraCachexia Research Laboratory, Exercise Science Research Center, Department of Health, Human Performance and Recreation, University of Arkansas, Fayetteville, Arkansas, United States.ORCID 0000-0002-9811-3585
Ronald G JonesMolecular Muscle Mass Regulation Laboratory, Exercise Science Research Center, Department of Health, Human Performance and Recreation, University of Arkansas, Fayetteville, Arkansas, United States.
Eleanor R ShremsExercise Muscle Biology Laboratory, Exercise Science Research Center, Department of Health, Human Performance and Recreation, University of Arkansas, Fayetteville, Arkansas, United States.
Francielly MorenaCachexia Research Laboratory, Exercise Science Research Center, Department of Health, Human Performance and Recreation, University of Arkansas, Fayetteville, Arkansas, United States.ORCID 0000-0001-5019-2125
Yuan WenDivision of Biomedical Informatics, Department of Internal Medicine, College of Medicine, University of Kentucky, Lexington, Kentucky, United States.ORCID 0000-0002-3210-1629
Tyrone A WashingtonExercise Muscle Biology Laboratory, Exercise Science Research Center, Department of Health, Human Performance and Recreation, University of Arkansas, Fayetteville, Arkansas, United States.ORCID 0000-0002-1919-5907
Kevin A MurachMolecular Muscle Mass Regulation Laboratory, Exercise Science Research Center, Department of Health, Human Performance and Recreation, University of Arkansas, Fayetteville, Arkansas, United States.ORCID 0000-0003-2783-7137
Nicholas P GreeneCachexia Research Laboratory, Exercise Science Research Center, Department of Health, Human Performance and Recreation, University of Arkansas, Fayetteville, Arkansas, United States.ORCID 0000-0001-9621-2005

Funding

Understanding the Negative Prognostic Impact of Intraosseous Focal Lesions in Multiple MyelomaP20GM125503 · NIGMS · UNIV OF ARKANSAS FOR MED SCIS · PI Qiang Fu · 2018 to 2026
$23.0M
DEVELOPMENT OF TARGETED APPROACHES IN PREVENTION OF CANCER-CACHEXIAR01AR075794 · NIAMS · UNIVERSITY OF ARKANSAS AT FAYETTEVILLE · PI GREENE, NICHOLAS PERRY · 2020 to 2024
$1.6M
Arkansas Biosciences Institute (ABI)HHS | NIH | National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) R01AR075794-01A1/AR/NIAMS (NPG)HHS | NIH | National Institute of General Medical Sciences (NIGMS) P20GM125503NIAMS NIH HHS R01 AR075794NIGMS NIH HHS P20 GM125503
6 · The paper itself

Abstract

Cancer cachexia is a wasting condition, primarily affecting skeletal muscle, impairing patients' quality of life, prognosis, and survival. The molecular triggers are incompletely defined, but given prior evidence for epigenetic plasticity in muscle, we speculate that dysregulated DNA methylation plays a role in muscle transcriptional alterations mediating cachexia severity. We aimed to describe and integrate the cachexia methylome and transcriptome. We used a time course approach in a mild cachexia model (colon-26, C26) coupled with a severe cachexia genetic model (

Indexed as

CachexiaColorectal NeoplasmsDNA MethylationEpigenomeMuscle, SkeletalTranscriptomeAnimalsDisease ProgressionEpigenesis, GeneticFemaleMaleMiceMice, Inbred C57BLbiological sexepigeneticsmolecular signaturesomics integrationRunx1

Identifiers

PMID41385570
PMCPMC12848882

What Socratic holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.