Evidence map›Paper›PMID 41386220›Full record

ArticleCell metabolism2026

Bile acids regulate lipid metabolism through selective actions on fatty acid absorption.

Alvin P Chan, Kelsey E Jarrett, Rochelle W Lai, Madelaine C Brearley-Sholto, Angela S Cheng, Maria O Taveras, Anne M Iwata, Michelle E Steel, Andrew Lau, Emily C Whang and 9 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell metabolism, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
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  6. Review
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  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Alvin P ChanDivision of Cardiology, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles (UCLA), Los Angeles, CA 90095, USA; Division of Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, Mattel Children's Hospital, David Geffen School of Medicine, University of California, Los Angeles (UCLA), Los Angeles, CA 90095, USA.
Kelsey E JarrettDivision of Cardiology, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles (UCLA), Los Angeles, CA 90095, USA.
Rochelle W LaiDivision of Cardiology, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles (UCLA), Los Angeles, CA 90095, USA.
Madelaine C Brearley-SholtoDivision of Cardiology, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles (UCLA), Los Angeles, CA 90095, USA.
Angela S ChengDepartment of Biological Chemistry, David Geffen School of Medicine, University of California, Los Angeles (UCLA), Los Angeles, CA 90095, USA.
Maria O TaverasDepartment of Biological Chemistry, David Geffen School of Medicine, University of California, Los Angeles (UCLA), Los Angeles, CA 90095, USA.
Anne M IwataDepartment of Biological Chemistry, David Geffen School of Medicine, University of California, Los Angeles (UCLA), Los Angeles, CA 90095, USA.
Michelle E SteelDivision of Cardiology, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles (UCLA), Los Angeles, CA 90095, USA.
Andrew LauDivision of Cardiology, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles (UCLA), Los Angeles, CA 90095, USA.
Emily C WhangDivision of Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, Mattel Children's Hospital, David Geffen School of Medicine, University of California, Los Angeles (UCLA), Los Angeles, CA 90095, USA.
John P KennellyDepartment of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California, Los Angeles (UCLA), Los Angeles, CA 90095, USA.
Yajing GaoDepartment of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California, Los Angeles (UCLA), Los Angeles, CA 90095, USA.
Gabriella E RubertDivision of Cardiology, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles (UCLA), Los Angeles, CA 90095, USA; Molecular Biology Institute, University of California, Los Angeles (UCLA), Los Angeles, CA 90095, USA.
Heidi M SchmidtDivision of Cardiology, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles (UCLA), Los Angeles, CA 90095, USA.
Emily P SmithDivision of Cardiology, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles (UCLA), Los Angeles, CA 90095, USA; Molecular Biology Institute, University of California, Los Angeles (UCLA), Los Angeles, CA 90095, USA.
Baolong SuDepartment of Biological Chemistry, David Geffen School of Medicine, University of California, Los Angeles (UCLA), Los Angeles, CA 90095, USA; UCLA Lipidomics Laboratory, University of California, Los Angeles (UCLA), Los Angeles, CA 90095, USA.
Kevin J WilliamsDepartment of Biological Chemistry, David Geffen School of Medicine, University of California, Los Angeles (UCLA), Los Angeles, CA 90095, USA; UCLA Lipidomics Laboratory, University of California, Los Angeles (UCLA), Los Angeles, CA 90095, USA.
Elizabeth J TarlingDivision of Cardiology, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles (UCLA), Los Angeles, CA 90095, USA; Jonsson Comprehensive Cancer Center (JCCC), University of California, Los Angeles (UCLA), Los Angeles, CA 90095, USA; Molecular Biology Institute, University of California, Los Angeles (UCLA), Los Angeles, CA 90095, USA.
Thomas Q de Aguiar VallimDivision of Cardiology, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles (UCLA), Los Angeles, CA 90095, USA; Department of Biological Chemistry, David Geffen School of Medicine, University of California, Los Angeles (UCLA), Los Angeles, CA 90095, USA; Jonsson Comprehensive Cancer Center (JCCC), University of California, Los Angeles (UCLA), Los Angeles, CA 90095, USA; Molecular Biology Institute, University of California, Los Angeles (UCLA), Los Angeles, CA 90095, USA. Electronic address: tvallim@mednet.ucla.edu.

Funding

UCLA Clinical Translational Science InstituteUL1TR001881 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ARLEEN F. BROWN, ARASH NAEIM · 2016 to 2026
$118.1M
Transgenic & Knock-out MouseP30DK063491 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ALAN R. SALTIEL · 2003 to 2026
$40.4M
GASTROENTEROLOGYT32DK007180 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI JENSEN, DENNIS MICHAEL · 1986 to 2025
$10.0M
Training Grant in Genomic Analysis and InterpretationT32HG002536 · NHGRI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Valerie A Arboleda, Harold Pimentel · 2002 to 2026
$8.6M
The impact of estrogen receptor alpha on cardiomyocellular metabolism and healthU54HL170326 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Hooman Allayee · 2023 to 2026
$7.5M
Vascular Biology Training GrantT32HL069766 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI LUSIS, ALDONS JAKE · 2002 to 2022
$7.4M
Research Training in Cell and Molecular BiologyT32GM145388 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Jorge Torres · 2022 to 2026
$5.2M
Targeting the gut-liver axis in cardiovascular diseaseR01HL163908 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Elizabeth Joanna Tarling, Thomas A Vallim · 2023 to 2026
$2.9M
Post-transcriptional regulation of LDLRR01HL174008 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Elizabeth Joanna Tarling, Thomas A Vallim · 2024 to 2026
$2.5M
ATP Binding Cassette Transporters in Health and DiseaseR01DK128952 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI TARLING, ELIZABETH JOANNA, VALLIM, THOMAS A · 2021 to 2024
$2.4M
Bile acid-mediated control of lipid absorption and fatty liver diseaseR01DK138340 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Thomas A Vallim · 2024 to 2026
$1.9M
Novel Post-Transcriptional Regulators of Lipid MetabolismR01DK112119 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI VALLIM, THOMAS A · 2017 to 2020
$1.7M
NCATS NIH HHS UL1 TR001881NHGRI NIH HHS T32 HG002536NHLBI NIH HHS R01 HL163908NHLBI NIH HHS R01 HL174008NHLBI NIH HHS T32 HL069766NHLBI NIH HHS U54 HL170326NICHD NIH HHS K12 HD111040NIDDK NIH HHS F31 DK138752NIDDK NIH HHS K99 DK138289NIDDK NIH HHS P30 DK063491NIDDK NIH HHS R01 DK112119NIDDK NIH HHS R01 DK128952NIDDK NIH HHS R01 DK138340NIDDK NIH HHS R01 DK144132NIDDK NIH HHS T32 DK007180NIGMS NIH HHS T32 GM145388
6 · The paper itself

Abstract

Intestinal lipid absorption, the entry point for fats into the body, requires the coordinated actions of bile acids and lipases. Here, we uncover distinct yet cooperative roles of bile acids in driving the differential uptake of dietary fatty acids. We first decreased the bile acid pool size by disrupting the rate-limiting enzyme in bile acid synthesis, Cyp7a1, using liver-directed gene editing in mice. Compared with lipase inhibition, reduced bile acids prevented diet-induced obesity, increased anorectic hormones, suppressed excessive eating, and improved systemic lipid metabolism. Remarkably, decreasing bile acids selectively reduced the absorption of saturated fatty acids but preserved polyunsaturated fatty acids. By targeting additional bile acid enzymes, we identified specific functions of individual bile acid species. Mechanistically, we show that cholic acid preferentially solubilizes polyunsaturated fatty acids into mixed micelles for intestinal uptake. Our studies demonstrate that bile acids can selectively control fatty acid uptake, revealing insights for future interventions in metabolic diseases.

Indexed as

Bile Acids and SaltsDietary FatsFatty AcidsIntestinal AbsorptionLipid MetabolismAnimalsHumansIncretinsMaleMiceMice, Inbred C57BLBile Acids and SaltsDietary FatsFatty AcidsIncretinsbile acidsCYP2A12CYP2C70CYP7A1CYP8B1fatty acidsGLP-1lipid absorptionlipogenesis

Identifiers

PMID41386220
PMCPMC12767720

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.